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- W1504355432 abstract "Objective : Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. In this study, we explored the genetic causes of alcohol dependence by comparing the frequency of the tryptophan hydroxylase(TPH) A218C between patients with alcohol dependence and control subjects in Korean population. We also explored the association between TPH A218C polymorphism and clinical characteristics in patients with alcohol dependence. Method : The genotype and allele frequencies of TPH were investigated in 182 normal control and 162 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-Ⅳ) criteria for alcohol dependence. We conducted clinical assessments using Alcohol Dependence Scale(ADS), Beck Depression Inventory, Beck Anxiety Inventory, and Obsessive-Compulsive Drinking Scale. Results : The frequency of AA genotype and A allele is higher in patients with alcohol dependence than in normal control. Alcoholics with the TPH CC or AC genotypes had a later age of disease onset(mean age of onset, 33.6 and 30.5 years, respectively) than those with the AA genotype(mean age of onset, 25.8 years ; p＜0.001). Also we found the TPH AA genotype has a higher score on the Korean version of the ADS than those with CC genotypes(p=0.001). Conclusion : Our results suggest that TPH polymorphism may be a crucial factor in the development of alcohol dependence and may explain, in part, the biological basis for these typologies." @default.
- W1504355432 created "2016-06-24" @default.
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- W1504355432 date "2006-06-01" @default.
- W1504355432 modified "2023-09-24" @default.
- W1504355432 title "한국인 집단에서 알코올 의존과 Tryptophan Hydroxylase A218C 유전자 다형성의 연관성" @default.
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