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- W1504418083 endingPage "5052" @default.
- W1504418083 startingPage "5047" @default.
- W1504418083 abstract "MicroRNAs (miRNAs) are endogenous oligoribonucleotides with exciting therapeutic potential. Early studies established a clear role for miRNAs in leukocyte biology. The first miRNA-based therapy, miravirsen, is now in phase 2 clinical trials, making the reality of these therapies undeniable. The capacity for miRNAs to fine-tune inflammatory signaling make them attractive treatment targets for immunological diseases. Nonetheless, the degree of redundancy among miRNAs, coupled with the promiscuity of miRNA binding sites in the transcriptome, require consideration when designing miRNA-directed interventions. Altered miRNA expression occurs across a range of inflammatory conditions, including inflammatory bowel disease, arthritis, and diabetes. However, very few studies successfully treated murine models of immunological diseases with miRNA-based approaches. While discussing recent studies targeting miRNAs to treat immunological conditions, we also reflect on the risks of miRNA targeting and showcase some newer delivery systems that may improve the pharmacological profile of this class of therapeutics." @default.
- W1504418083 created "2016-06-24" @default.
- W1504418083 creator A5042292777 @default.
- W1504418083 creator A5053814898 @default.
- W1504418083 creator A5079216187 @default.
- W1504418083 date "2015-05-15" @default.
- W1504418083 modified "2023-10-14" @default.
- W1504418083 title "Prospects for Therapeutic Targeting of MicroRNAs in Human Immunological Diseases" @default.
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