FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504439746> ?p ?o ?g. }

• W1504439746 endingPage "912" @default.
• W1504439746 startingPage "903" @default.
• W1504439746 abstract "Increased intrauterine prostaglandin (PG) production is crucial for the initiation of parturition. To investigate the mechanisms controlling intrauterine PG synthesis, we examined the expression of the key PG biosynthetic isoenzymes, PG‐H 2 synthase (PTGS)‐1 and ‐2, in the amnion, visceral yolk sac (VYS), placenta and myo‐endometrium of pregnant guinea pigs. This animal model was chosen because the hormonal milieu of pregnancy and the role of PGs in the hormonal control of parturition are similar to those in the human. PTGS1 mRNA abundance, measured by real‐time RT‐PCR, increased in the amnion and the placenta during the last third of gestation. During labour, PTGS1 mRNA levels decreased precipitously in all four tissues. PTGS1 protein abundance, assessed by immunoblotting, increased to high levels in the amnion and the placenta by the end of pregnancy and remained high during labour. PTGS2 mRNA expression was higher in the placenta than in the other tissues, but did not change before and during labour. PTGS2 protein expression decreased in the placenta and remained low in the other tissues during labour. Immunohistochemistry showed pervasive PTGS1 protein expression in the amnion and strong expression in the parietal yolk sac membrane (PYS) covering the placenta. PTGS2 was expressed in the PYS and the endometrium. The PTGS inhibitor piroxicam, administered in doses that inhibited PTGS1 but not PTGS2, significantly prolonged gestation. These data suggest that PGs generated by intrauterine PTGS1 are involved in the timing of birth in guinea pigs. The induction of PTGS1 in the amnion and the PYS is a critical event leading to labour in guinea pigs and models analogous changes in the human gestational tissues before labour." @default.
• W1504439746 created "2016-06-24" @default.
• W1504439746 creator A5064174666 @default.
• W1504439746 creator A5075951981 @default.
• W1504439746 creator A5084239794 @default.
• W1504439746 creator A5084692144 @default.
• W1504439746 creator A5086813714 @default.
• W1504439746 date "2005-12-01" @default.
• W1504439746 modified "2023-10-12" @default.
• W1504439746 title "Prostaglandin H₂synthase-1 and -2 expression in guinea pig gestational tissues during late pregnancy and parturition" @default.
• W1504439746 cites W1536681507 @default.
• W1504439746 cites W1668732801 @default.
• W1504439746 cites W1758121263 @default.
• W1504439746 cites W1967214325 @default.
• W1504439746 cites W1976971276 @default.
• W1504439746 cites W1982525919 @default.
• W1504439746 cites W1983003192 @default.
• W1504439746 cites W1997100253 @default.
• W1504439746 cites W2006776787 @default.
• W1504439746 cites W2009924882 @default.
• W1504439746 cites W2014553384 @default.
• W1504439746 cites W2021030634 @default.
• W1504439746 cites W2028000180 @default.
• W1504439746 cites W2028082430 @default.
• W1504439746 cites W2030755050 @default.
• W1504439746 cites W2033691439 @default.
• W1504439746 cites W2056231731 @default.
• W1504439746 cites W2060370324 @default.
• W1504439746 cites W2061470055 @default.
• W1504439746 cites W2082770926 @default.
• W1504439746 cites W2102368544 @default.
• W1504439746 cites W2107277218 @default.
• W1504439746 cites W2108161486 @default.
• W1504439746 cites W2109258478 @default.
• W1504439746 cites W2129666165 @default.
• W1504439746 cites W2145711885 @default.
• W1504439746 cites W2148955233 @default.
• W1504439746 cites W2165276815 @default.
• W1504439746 cites W2192080449 @default.
• W1504439746 cites W2415192937 @default.
• W1504439746 cites W4236395061 @default.
• W1504439746 cites W4251760973 @default.
• W1504439746 cites W1978695342 @default.
• W1504439746 doi "https://doi.org/10.1113/jphysiol.2005.098129" @default.
• W1504439746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1464277" @default.
• W1504439746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16239272" @default.
• W1504439746 hasPublicationYear "2005" @default.
• W1504439746 type Work @default.
• W1504439746 sameAs 1504439746 @default.
• W1504439746 citedByCount "16" @default.
• W1504439746 countsByYear W15044397462012 @default.
• W1504439746 countsByYear W15044397462013 @default.
• W1504439746 countsByYear W15044397462014 @default.
• W1504439746 countsByYear W15044397462015 @default.
• W1504439746 countsByYear W15044397462017 @default.
• W1504439746 countsByYear W15044397462018 @default.
• W1504439746 countsByYear W15044397462020 @default.
• W1504439746 crossrefType "journal-article" @default.
• W1504439746 hasAuthorship W1504439746A5064174666 @default.
• W1504439746 hasAuthorship W1504439746A5075951981 @default.
• W1504439746 hasAuthorship W1504439746A5084239794 @default.
• W1504439746 hasAuthorship W1504439746A5084692144 @default.
• W1504439746 hasAuthorship W1504439746A5086813714 @default.
• W1504439746 hasBestOaLocation W15044397462 @default.
• W1504439746 hasConcept C126322002 @default.
• W1504439746 hasConcept C134018914 @default.
• W1504439746 hasConcept C16685009 @default.
• W1504439746 hasConcept C172680121 @default.
• W1504439746 hasConcept C196843134 @default.
• W1504439746 hasConcept C2776953305 @default.
• W1504439746 hasConcept C2777043721 @default.
• W1504439746 hasConcept C2779234561 @default.
• W1504439746 hasConcept C2779742232 @default.
• W1504439746 hasConcept C2780646683 @default.
• W1504439746 hasConcept C54355233 @default.
• W1504439746 hasConcept C71924100 @default.
• W1504439746 hasConcept C86803240 @default.
• W1504439746 hasConcept C95444343 @default.
• W1504439746 hasConceptScore W1504439746C126322002 @default.
• W1504439746 hasConceptScore W1504439746C134018914 @default.
• W1504439746 hasConceptScore W1504439746C16685009 @default.
• W1504439746 hasConceptScore W1504439746C172680121 @default.
• W1504439746 hasConceptScore W1504439746C196843134 @default.
• W1504439746 hasConceptScore W1504439746C2776953305 @default.
• W1504439746 hasConceptScore W1504439746C2777043721 @default.
• W1504439746 hasConceptScore W1504439746C2779234561 @default.
• W1504439746 hasConceptScore W1504439746C2779742232 @default.
• W1504439746 hasConceptScore W1504439746C2780646683 @default.
• W1504439746 hasConceptScore W1504439746C54355233 @default.
• W1504439746 hasConceptScore W1504439746C71924100 @default.
• W1504439746 hasConceptScore W1504439746C86803240 @default.
• W1504439746 hasConceptScore W1504439746C95444343 @default.
• W1504439746 hasIssue "3" @default.
• W1504439746 hasLocation W15044397461 @default.
• W1504439746 hasLocation W15044397462 @default.
• W1504439746 hasLocation W15044397463 @default.
• W1504439746 hasOpenAccess W1504439746 @default.
• W1504439746 hasPrimaryLocation W15044397461 @default.

• next