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• W1504490139 abstract "Abdominal aortic aneurysms (AAA) are permanent, irreversible, localised dilatations of they aorta. Usually, they develop as a result of a progressive localised weakness within the vessel wall. They typically occur below the level of the renal arteries and have a high propensity for rupture. In fact, ruptured AAAs account for approximately 8,000 and 15,000 deaths in the United Kingdom (UK) and United States of America (USA) respectively on an annual basis (Sakalihasan et al. 2005, Thompson 2003, Vorp and Vande Geest 2005). Risk factors for their development include male gender, age >65 and a history of smoking. Other associated risk factors are connective tissue disorders that typically have a genetic predisposition, syphilitic infections and cystic medial necrosis. Currently, there are two surgical treatments for AAA; the traditional open repair and a minimally invasive procedure known as endovascular aneurysm repair (EVAR) (Kamineni and Heuser 2004, Parodi et al. 1991, Sakalihasan et al. 2005). The endovascular technique has been widely applied in clinical practice, however important limitations persist (Egelhoff et al. 1999, Kamineni and Heuser 2004, Parodi et al. 1991). Among these limitations are device migration, endoleaks, and thrombotic occlusion. It has been suggested that tissueengineered xenografts may play a role for preventing these complications in EVAR. In the present chapter we discuss limitations of stent-grafts deployed in the EVAR procedure. We place particular emphasis on tissue-engineered extracellular matrices (ECMs) as adjuvant scaffolds for optimisation of the EVAR procedure." @default.
• W1504490139 created "2016-06-24" @default.
• W1504490139 creator A5016934366 @default.
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• W1504490139 creator A5070765309 @default.
• W1504490139 creator A5080846977 @default.
• W1504490139 date "2011-08-29" @default.
• W1504490139 modified "2023-09-30" @default.
• W1504490139 title "Tissue-Engineered Extracellular Matrices (ECMs) as Adjuvant Scaffolds for Endovascular Aneurysmal Repair (EVAR)" @default.
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• W1504490139 doi "https://doi.org/10.5772/21334" @default.
• W1504490139 hasPublicationYear "2011" @default.
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