Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504511102> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W1504511102 endingPage "47" @default.
- W1504511102 startingPage "37" @default.
- W1504511102 abstract "Although it is unclear how a living cell senses gravitational forces there is no doubt that perturbation of the gravitational environment results in profound alterations in cellular function. In the present study, we have focused our attention on how acute microgravity exposure during parabolic flight affects the skeletal muscle cell plasma membrane (i.e. sarcolemma), with specific reference to a mechanically-reactive signaling mechanism known as mechanically-induced membrane disruption or wounding. Both membrane rupture and membrane resealing events mediated by membrane-membrane fusion characterize this response. We here present experimental evidence that acute microgravity exposure can inhibit membrane-membrane fusion events essential for the resealing of sarcolemmal wounds in individual human myoblasts. Additional evidence to support this contention comes from experimental studies that demonstrate acute microgravity exposure also inhibits secretagogue-stimulated intracellular vesicle fusion with the plasma membrane in HL-60 cells. Based on our own observations and those of other investigators in a variety of ground-based models of membrane wounding and membrane-membrane fusion, we suggest that the disruption in the membrane resealing process observed during acute microgravity is consistent with a microgravity-induced decrease in membrane order." @default.
- W1504511102 created "2016-06-24" @default.
- W1504511102 creator A5009461463 @default.
- W1504511102 creator A5019612238 @default.
- W1504511102 creator A5029244649 @default.
- W1504511102 date "2001-12-01" @default.
- W1504511102 modified "2023-09-23" @default.
- W1504511102 title "The effect of acute microgravity on mechanically-induced membrane damage and membrane-membrane fusion events." @default.
- W1504511102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12365449" @default.
- W1504511102 hasPublicationYear "2001" @default.
- W1504511102 type Work @default.
- W1504511102 sameAs 1504511102 @default.
- W1504511102 citedByCount "3" @default.
- W1504511102 countsByYear W15045111022021 @default.
- W1504511102 crossrefType "journal-article" @default.
- W1504511102 hasAuthorship W1504511102A5009461463 @default.
- W1504511102 hasAuthorship W1504511102A5019612238 @default.
- W1504511102 hasAuthorship W1504511102A5029244649 @default.
- W1504511102 hasConcept C103038307 @default.
- W1504511102 hasConcept C12554922 @default.
- W1504511102 hasConcept C185592680 @default.
- W1504511102 hasConcept C199096232 @default.
- W1504511102 hasConcept C2778106830 @default.
- W1504511102 hasConcept C41625074 @default.
- W1504511102 hasConcept C55493867 @default.
- W1504511102 hasConcept C79879829 @default.
- W1504511102 hasConcept C86803240 @default.
- W1504511102 hasConcept C95444343 @default.
- W1504511102 hasConceptScore W1504511102C103038307 @default.
- W1504511102 hasConceptScore W1504511102C12554922 @default.
- W1504511102 hasConceptScore W1504511102C185592680 @default.
- W1504511102 hasConceptScore W1504511102C199096232 @default.
- W1504511102 hasConceptScore W1504511102C2778106830 @default.
- W1504511102 hasConceptScore W1504511102C41625074 @default.
- W1504511102 hasConceptScore W1504511102C55493867 @default.
- W1504511102 hasConceptScore W1504511102C79879829 @default.
- W1504511102 hasConceptScore W1504511102C86803240 @default.
- W1504511102 hasConceptScore W1504511102C95444343 @default.
- W1504511102 hasIssue "2" @default.
- W1504511102 hasLocation W15045111021 @default.
- W1504511102 hasOpenAccess W1504511102 @default.
- W1504511102 hasPrimaryLocation W15045111021 @default.
- W1504511102 hasRelatedWork W1604932780 @default.
- W1504511102 hasRelatedWork W170657707 @default.
- W1504511102 hasRelatedWork W2051222366 @default.
- W1504511102 hasRelatedWork W2109274045 @default.
- W1504511102 hasRelatedWork W2168873421 @default.
- W1504511102 hasRelatedWork W218296870 @default.
- W1504511102 hasRelatedWork W2567298666 @default.
- W1504511102 hasRelatedWork W4213176072 @default.
- W1504511102 hasRelatedWork W4290253143 @default.
- W1504511102 hasRelatedWork W8232247 @default.
- W1504511102 hasVolume "8" @default.
- W1504511102 isParatext "false" @default.
- W1504511102 isRetracted "false" @default.
- W1504511102 magId "1504511102" @default.
- W1504511102 workType "article" @default.