FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504530997> ?p ?o ?g. }

• W1504530997 abstract "In addition to alpha1A, alpha1B and alpha1D-adrenoceptors (ARs), putative alpha1L-ARs with a low affinity for prazosin have been proposed. The purpose of the present study was to identify the alpha1A-AR and clarify its pharmacological profile using a radioligand binding assay.Binding experiments with [3H]-silodosin and [3H]-prazosin were performed in intact tissue segments and crude membrane preparations of rat cerebral cortex. Intact tissue binding assays were also conducted in rat tail artery.[3H]-silodosin at subnanomolar concentrations specifically bound to intact tissue segments and membrane preparations of rat cerebral cortex at the same density (approximately 150 fmol mg(-1) total tissue protein). The binding sites in intact segments consisted of alpha1A and alpha1L-ARs that had different affinities for prazosin, while the binding sites in membranes showed an alpha1A-AR-like profile having single high affinity for prazosin. [3H]-prazosin also bound at subnanomolar concentrations to alpha1A and alpha1B-ARs but not alpha1L-ARs in cerebral cortex; the binding densities being approximately 200 and 290 fmol mg(-1) protein in the segments and the membranes, respectively. In the segments of tail artery, [3H]-silodosin only recognized alpha1A-ARs, whereas [3H]-prazosin bound to alpha1A and alpha1B-ARs.The present study clearly reveals the presence of alpha1L-ARs as a pharmacologically distinct entity from alpha1A and alpha1B-ARs in intact tissue segments of rat cerebral cortex but not tail artery. However, the alpha1L-ARs disappeared after tissue homogenization, suggesting their decomposition and/or their pharmacological profile changes to that of alpha1A-ARs." @default.
• W1504530997 created "2016-06-24" @default.
• W1504530997 creator A5000186484 @default.
• W1504530997 creator A5025273249 @default.
• W1504530997 creator A5057775129 @default.
• W1504530997 creator A5062876325 @default.
• W1504530997 creator A5064758344 @default.
• W1504530997 creator A5077115512 @default.
• W1504530997 creator A5090563200 @default.
• W1504530997 date "2008-04-01" @default.
• W1504530997 modified "2023-10-13" @default.
• W1504530997 title "Identification of the α1L-adrenoceptor in rat cerebral cortex and possible relationship between α1L- and α1A-adrenoceptors" @default.
• W1504530997 cites W1815738849 @default.
• W1504530997 cites W1963590565 @default.
• W1504530997 cites W1966985666 @default.
• W1504530997 cites W1967088824 @default.
• W1504530997 cites W1972585642 @default.
• W1504530997 cites W1981897795 @default.
• W1504530997 cites W1985407755 @default.
• W1504530997 cites W1986286688 @default.
• W1504530997 cites W1997501241 @default.
• W1504530997 cites W2000643141 @default.
• W1504530997 cites W2006713897 @default.
• W1504530997 cites W2010346714 @default.
• W1504530997 cites W2010740081 @default.
• W1504530997 cites W2012810664 @default.
• W1504530997 cites W2014884270 @default.
• W1504530997 cites W2017436626 @default.
• W1504530997 cites W2024404276 @default.
• W1504530997 cites W2028050995 @default.
• W1504530997 cites W2035539636 @default.
• W1504530997 cites W2035986648 @default.
• W1504530997 cites W2037697488 @default.
• W1504530997 cites W2045158143 @default.
• W1504530997 cites W2048119462 @default.
• W1504530997 cites W2048373362 @default.
• W1504530997 cites W2056171969 @default.
• W1504530997 cites W2057803818 @default.
• W1504530997 cites W2059821888 @default.
• W1504530997 cites W2060111059 @default.
• W1504530997 cites W2060695236 @default.
• W1504530997 cites W2065635008 @default.
• W1504530997 cites W2069193260 @default.
• W1504530997 cites W2071951474 @default.
• W1504530997 cites W2082144819 @default.
• W1504530997 cites W2085176578 @default.
• W1504530997 cites W2090574173 @default.
• W1504530997 cites W2092281190 @default.
• W1504530997 cites W2104559308 @default.
• W1504530997 cites W2107883921 @default.
• W1504530997 cites W2121555927 @default.
• W1504530997 cites W2133612971 @default.
• W1504530997 cites W2137640567 @default.
• W1504530997 cites W2140869466 @default.
• W1504530997 cites W2157777953 @default.
• W1504530997 doi "https://doi.org/10.1038/sj.bjp.0707679" @default.
• W1504530997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2437907" @default.
• W1504530997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18223667" @default.
• W1504530997 hasPublicationYear "2008" @default.
• W1504530997 type Work @default.
• W1504530997 sameAs 1504530997 @default.
• W1504530997 citedByCount "23" @default.
• W1504530997 countsByYear W15045309972012 @default.
• W1504530997 countsByYear W15045309972013 @default.
• W1504530997 countsByYear W15045309972014 @default.
• W1504530997 countsByYear W15045309972019 @default.
• W1504530997 crossrefType "journal-article" @default.
• W1504530997 hasAuthorship W1504530997A5000186484 @default.
• W1504530997 hasAuthorship W1504530997A5025273249 @default.
• W1504530997 hasAuthorship W1504530997A5057775129 @default.
• W1504530997 hasAuthorship W1504530997A5062876325 @default.
• W1504530997 hasAuthorship W1504530997A5064758344 @default.
• W1504530997 hasAuthorship W1504530997A5077115512 @default.
• W1504530997 hasAuthorship W1504530997A5090563200 @default.
• W1504530997 hasBestOaLocation W15045309972 @default.
• W1504530997 hasConcept C116834253 @default.
• W1504530997 hasConcept C126322002 @default.
• W1504530997 hasConcept C134018914 @default.
• W1504530997 hasConcept C169760540 @default.
• W1504530997 hasConcept C170493617 @default.
• W1504530997 hasConcept C185592680 @default.
• W1504530997 hasConcept C2776885963 @default.
• W1504530997 hasConcept C2780648677 @default.
• W1504530997 hasConcept C2908894505 @default.
• W1504530997 hasConcept C2909005528 @default.
• W1504530997 hasConcept C40465926 @default.
• W1504530997 hasConcept C59822182 @default.
• W1504530997 hasConcept C67847695 @default.
• W1504530997 hasConcept C71924100 @default.
• W1504530997 hasConcept C86803240 @default.
• W1504530997 hasConcept C98274493 @default.
• W1504530997 hasConceptScore W1504530997C116834253 @default.
• W1504530997 hasConceptScore W1504530997C126322002 @default.
• W1504530997 hasConceptScore W1504530997C134018914 @default.
• W1504530997 hasConceptScore W1504530997C169760540 @default.
• W1504530997 hasConceptScore W1504530997C170493617 @default.
• W1504530997 hasConceptScore W1504530997C185592680 @default.
• W1504530997 hasConceptScore W1504530997C2776885963 @default.
• W1504530997 hasConceptScore W1504530997C2780648677 @default.
• W1504530997 hasConceptScore W1504530997C2908894505 @default.

• next