FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504534905> ?p ?o ?g. }

• W1504534905 endingPage "243" @default.
• W1504534905 startingPage "231" @default.
• W1504534905 abstract "Elucidating the age-dependent alterations in transgenic (Tg) mice overexpressing amyloid-β protein precursor (AβPP) is important for understanding the pathogenesis of Alzheimer's disease (AD) and designing experimental therapies. Cross-studies have previously characterized some time-dependent behavioral and pathological alterations in AβPP Tg mice, however, a more comprehensive longitudinal study is needed to fully examine the progressive nature of behavioral deficits in these mice. In order to better understand the age- and gender-dependent progression of behavioral alterations, we performed a longitudinal study wherein Tg mice overexpressing human AβPP751 with the London (V717I) and Swedish (K670M/N671L) mutations under the regulatory control of the neuron specific murine (m)Thy-1 promoter (mThy1-hAβPP751) were behaviorally analyzed at 3 months and then re-tested at 6 and 9 months of age. The results show that there was an age-associated impairment in learning in the water maze task and habituation in the hole-board task. Motor coordination of the mThy1-hAβPP751 Tg mice was well-preserved throughout the investigated life span however, gender-specific deficits were observed in spontaneous activity and thigmotaxis. Neuropathologically, mThy1-hAβPP751 Tg mice displayed a progressive increase in the number of Aβ plaques and mean plaque size in the cortex and hippocampus from 3 to 6 and from 6 to 9 months of age. Taken together, these results indicate that the mThy1-hAβPP751 Tg mice model AD from the early onset of the disease through to later stages, allowing them to be utilized at numerous points during the timeline for drug test designs." @default.
• W1504534905 created "2016-06-24" @default.
• W1504534905 creator A5042907016 @default.
• W1504534905 creator A5059245902 @default.
• W1504534905 creator A5065203513 @default.
• W1504534905 creator A5074775445 @default.
• W1504534905 creator A5078691701 @default.
• W1504534905 creator A5079575909 @default.
• W1504534905 creator A5082198577 @default.
• W1504534905 date "2011-07-01" @default.
• W1504534905 modified "2023-10-04" @default.
• W1504534905 title "A Longitudinal Study of Behavioral Deficits in an AβPP Transgenic Mouse Model of Alzheimer's Disease" @default.
• W1504534905 cites W127741752 @default.
• W1504534905 cites W180043528 @default.
• W1504534905 cites W1929267935 @default.
• W1504534905 cites W1964215424 @default.
• W1504534905 cites W1964473837 @default.
• W1504534905 cites W1967329061 @default.
• W1504534905 cites W1973017204 @default.
• W1504534905 cites W1975627206 @default.
• W1504534905 cites W1983197297 @default.
• W1504534905 cites W1984268151 @default.
• W1504534905 cites W1985613394 @default.
• W1504534905 cites W1989272234 @default.
• W1504534905 cites W1990752558 @default.
• W1504534905 cites W1999463998 @default.
• W1504534905 cites W2001210466 @default.
• W1504534905 cites W2004739315 @default.
• W1504534905 cites W2007018177 @default.
• W1504534905 cites W2008767130 @default.
• W1504534905 cites W2014898742 @default.
• W1504534905 cites W2017429750 @default.
• W1504534905 cites W2020611752 @default.
• W1504534905 cites W2020951538 @default.
• W1504534905 cites W2024262813 @default.
• W1504534905 cites W2025561374 @default.
• W1504534905 cites W2038072430 @default.
• W1504534905 cites W2041512773 @default.
• W1504534905 cites W2049471629 @default.
• W1504534905 cites W2053488262 @default.
• W1504534905 cites W2059157160 @default.
• W1504534905 cites W2060851420 @default.
• W1504534905 cites W2074994510 @default.
• W1504534905 cites W2081095372 @default.
• W1504534905 cites W2083752135 @default.
• W1504534905 cites W2086333867 @default.
• W1504534905 cites W2086572083 @default.
• W1504534905 cites W2089676562 @default.
• W1504534905 cites W2091745370 @default.
• W1504534905 cites W2104757313 @default.
• W1504534905 cites W2109727228 @default.
• W1504534905 cites W2126800086 @default.
• W1504534905 cites W2150231759 @default.
• W1504534905 cites W2152304945 @default.
• W1504534905 cites W2156326104 @default.
• W1504534905 cites W2257257171 @default.
• W1504534905 cites W2401309054 @default.
• W1504534905 cites W2473341021 @default.
• W1504534905 doi "https://doi.org/10.3233/jad-2011-101866" @default.
• W1504534905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4944527" @default.
• W1504534905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21403389" @default.
• W1504534905 hasPublicationYear "2011" @default.
• W1504534905 type Work @default.
• W1504534905 sameAs 1504534905 @default.
• W1504534905 citedByCount "40" @default.
• W1504534905 countsByYear W15045349052012 @default.
• W1504534905 countsByYear W15045349052013 @default.
• W1504534905 countsByYear W15045349052014 @default.
• W1504534905 countsByYear W15045349052015 @default.
• W1504534905 countsByYear W15045349052016 @default.
• W1504534905 countsByYear W15045349052017 @default.
• W1504534905 countsByYear W15045349052018 @default.
• W1504534905 countsByYear W15045349052020 @default.
• W1504534905 countsByYear W15045349052021 @default.
• W1504534905 countsByYear W15045349052022 @default.
• W1504534905 countsByYear W15045349052023 @default.
• W1504534905 crossrefType "journal-article" @default.
• W1504534905 hasAuthorship W1504534905A5042907016 @default.
• W1504534905 hasAuthorship W1504534905A5059245902 @default.
• W1504534905 hasAuthorship W1504534905A5065203513 @default.
• W1504534905 hasAuthorship W1504534905A5074775445 @default.
• W1504534905 hasAuthorship W1504534905A5078691701 @default.
• W1504534905 hasAuthorship W1504534905A5079575909 @default.
• W1504534905 hasAuthorship W1504534905A5082198577 @default.
• W1504534905 hasBestOaLocation W15045349052 @default.
• W1504534905 hasConcept C102230213 @default.
• W1504534905 hasConcept C104317684 @default.
• W1504534905 hasConcept C126322002 @default.
• W1504534905 hasConcept C134018914 @default.
• W1504534905 hasConcept C141035611 @default.
• W1504534905 hasConcept C15744967 @default.
• W1504534905 hasConcept C169760540 @default.
• W1504534905 hasConcept C207886595 @default.
• W1504534905 hasConcept C2779085643 @default.
• W1504534905 hasConcept C2779134260 @default.
• W1504534905 hasConcept C2780942790 @default.
• W1504534905 hasConcept C2781161787 @default.
• W1504534905 hasConcept C2910500303 @default.

• next