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• W1504561806 abstract "Motivated by the promises of gene therapy, there is great interest in developing non-viral lipid-based vectors for therapeutic applications due to their low immunogenicity, low toxicity, ease of production, and the potential of transferring large pieces of DNA into cells. In fact, cationic liposome (CL) based vectors are among the prevalent synthetic carriers of nucleic acids (NAs) currently used in gene therapy clinical trials worldwide. These vectors are studied both for gene delivery with CL–DNA complexes and gene silencing with CL–siRNA (short interfering RNA) complexes. However, their transfection efficiencies and silencing efficiencies remain low compared to those of engineered viral vectors. This reflects the currently poor understanding of transfection-related mechanisms at the molecular and self-assembled levels, including a lack of knowledge about interactions between membranes and double stranded NAs and between CL–NA complexes and cellular components. In this review we describe our recent efforts to improve the mechanistic understanding of transfection by CL–NA complexes, which will help to design optimal lipid-based carriers of DNA and siRNA for therapeutic gene delivery and gene silencing." @default.
• W1504561806 created "2016-06-24" @default.
• W1504561806 creator A5003298888 @default.
• W1504561806 creator A5003901731 @default.
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• W1504561806 creator A5051137544 @default.
• W1504561806 creator A5072488580 @default.
• W1504561806 creator A5083290739 @default.
• W1504561806 date "2010-01-01" @default.
• W1504561806 modified "2023-10-17" @default.
• W1504561806 title "Cationic Liposome–Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA" @default.
• W1504561806 cites W1410137816 @default.
• W1504561806 cites W1518586105 @default.
• W1504561806 cites W1591298544 @default.
• W1504561806 cites W1602020336 @default.
• W1504561806 cites W1611419331 @default.
• W1504561806 cites W1647075334 @default.
• W1504561806 cites W1968232819 @default.
• W1504561806 cites W1970885064 @default.
• W1504561806 cites W1971741270 @default.
• W1504561806 cites W1973805537 @default.
• W1504561806 cites W1975987895 @default.
• W1504561806 cites W1976117598 @default.
• W1504561806 cites W1976295444 @default.
• W1504561806 cites W1983338877 @default.
• W1504561806 cites W1986078859 @default.
• W1504561806 cites W1988289069 @default.
• W1504561806 cites W2001052983 @default.
• W1504561806 cites W2001836007 @default.
• W1504561806 cites W2002903271 @default.
• W1504561806 cites W2003295354 @default.
• W1504561806 cites W2003470252 @default.
• W1504561806 cites W2003904826 @default.
• W1504561806 cites W2003993864 @default.
• W1504561806 cites W2009642901 @default.
• W1504561806 cites W2010655741 @default.
• W1504561806 cites W2012092900 @default.
• W1504561806 cites W2014356856 @default.
• W1504561806 cites W2015601634 @default.
• W1504561806 cites W2017991840 @default.
• W1504561806 cites W2020850118 @default.
• W1504561806 cites W2022784062 @default.
• W1504561806 cites W2023104469 @default.
• W1504561806 cites W2027050448 @default.
• W1504561806 cites W2030330503 @default.
• W1504561806 cites W2033301315 @default.
• W1504561806 cites W2034486404 @default.
• W1504561806 cites W2043764483 @default.
• W1504561806 cites W2044637168 @default.
• W1504561806 cites W2045101135 @default.
• W1504561806 cites W2048393933 @default.
• W1504561806 cites W2048446993 @default.
• W1504561806 cites W2050347642 @default.
• W1504561806 cites W2052312685 @default.
• W1504561806 cites W2054796160 @default.
• W1504561806 cites W2057402201 @default.
• W1504561806 cites W2058598015 @default.
• W1504561806 cites W2060176427 @default.
• W1504561806 cites W2060475454 @default.
• W1504561806 cites W2062595050 @default.
• W1504561806 cites W2065051465 @default.
• W1504561806 cites W2067087235 @default.
• W1504561806 cites W2069800517 @default.
• W1504561806 cites W2077462718 @default.
• W1504561806 cites W2079835662 @default.
• W1504561806 cites W2092770422 @default.
• W1504561806 cites W2099113192 @default.
• W1504561806 cites W2099871857 @default.
• W1504561806 cites W2105277037 @default.
• W1504561806 cites W2105822696 @default.
• W1504561806 cites W2107235611 @default.
• W1504561806 cites W2115442536 @default.
• W1504561806 cites W2119522853 @default.
• W1504561806 cites W2123585553 @default.
• W1504561806 cites W2127497651 @default.
• W1504561806 cites W2128212057 @default.
• W1504561806 cites W2134077476 @default.
• W1504561806 cites W2136240349 @default.
• W1504561806 cites W2136447541 @default.
• W1504561806 cites W2136462695 @default.
• W1504561806 cites W2140268080 @default.
• W1504561806 cites W2145998984 @default.
• W1504561806 cites W2150738938 @default.
• W1504561806 cites W2151929256 @default.
• W1504561806 cites W2153378034 @default.
• W1504561806 cites W2155490034 @default.
• W1504561806 cites W2158273823 @default.
• W1504561806 cites W2162176191 @default.
• W1504561806 cites W2165652738 @default.
• W1504561806 cites W2165790671 @default.
• W1504561806 cites W2166013785 @default.
• W1504561806 cites W2264936970 @default.
• W1504561806 cites W2314516700 @default.
• W1504561806 cites W2356341070 @default.
• W1504561806 cites W2372887648 @default.
• W1504561806 cites W2945930932 @default.

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