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- W1504602752 abstract "The present study describes the effects of a 60-day isolation period on the salivary levels of cortisol and secretory IgA. The study took place in the context of the EXEMSI project in which four volunteers were isolated in a space station-like chamber in the DLR Institute of Aerospace Medicine in order to examine the effects of long term isolation. Inspection of the individual immunoglobulin A secretion rates revealed different patterns of cyclic variation with respect to the weekday-weekend schedule, and different time lags for the adaptation leading to a plateau for this parameter. The salivary cortisol levels showed a circadian rhythm with high concentrations in the early morning (7:30 am) and lower concentrations in the late evening (11:00 pm). Moreover, in all subjects marked increases of salivary cortisol were observed in a 12- to 14-day cycle. In two subjects the marked morning-evening differences were only visible at the weekends. The salivary cortisol and immunoglobulin A levels were determined twice weekly before and after completion of a complex decision-making test. The results reveal a changed responsiveness in all subjects at different times." @default.
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- W1504602752 date "1996-01-01" @default.
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- W1504602752 title "Chapter 7 Local Immunocompetence and Salivary Cortisol in Confinement" @default.
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- W1504602752 doi "https://doi.org/10.1016/s1569-2574(08)60056-8" @default.
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