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• W1504653456 abstract "Emodin, the major bioactive component of Rheum palmatum, has many different activities, including antitumor, anti-inflammatory, and antidiabetes effects. Recently, emodin was reported to regulate energy metabolism. In the present study, we further explored the effects of emodin on glucose and lipid metabolism. Differentiated C2C12 myotubes and 3T3-L1 adipocytes were treated with or without different concentrations of emodin (6.25, 12.5, 25 or 50 μmol/L) for different time (1 h, 3 h, 12 h, 24 h or 48 h). Glucose metabolism, oxygen consumption, lactic acid levels, glycerol levels, and inflammation pathways were then evaluated. Cells were collected for quantitative polymerase chain reaction (PCR) and western blot analysis. Emodin upregulated glucose uptake and consumption in both C2C12 myotubes and 3T3-L1 adipocytes, with glycolysis increased. Furthermore, emodin inhibited lipolysis under basal conditions (as well as in the presence of 10 ng/ml tumor necrosis factor (TNF-)-α in 3T3-L1 adipocytes) and significantly decreased phosphorylated perilipin. Moreover, emodin inhibited the nuclear factor-κB and extracellular signal-regulated kinase pathways in C2C12 myotubes and 3T3-L1 adipocytes. Emodin upregulates glucose metabolism, decreases lipolysis, and inhibits inflammation in C2C12 myotubes and 3T3-L1 adipocytes. 背景：大黄素是掌叶大黄的主要生物活性成分，具有多种的功效，包括抗肿瘤，抗炎以及预防糖尿病等作用。最近有报道大黄素具有调节能量代谢的作用。在本研究中，我们进一步探索大黄素对糖脂代谢的影响。 方法：用不同浓度的大黄素（6.25、12.5、25、50 μmol/L）分别处理或不处理分化成熟的C2C12骨骼肌细胞和3T3-L1脂肪细胞，作用不同时间（1 h、3 h、12 h、24 h、48 h）后，检测糖代谢、氧耗、乳酸水平、甘油释放及炎症通路。收集细胞进行Q-PCR及Western Blot检测。 结果：在C2C12骨骼肌细胞和3T3-L1脂肪细胞中，大黄素均能增加葡萄糖的摄取和消耗，同时伴随糖酵解的增加。大黄素可抑制基础状态的脂解（在3T3-L1脂肪细胞中肿瘤坏死因子[TNF-α]浓度为10 ng/mL），并显著降低脂滴表面蛋白（perilipin）的磷酸化水平。此外，在上述两种细胞中，大黄素对NF-kB和ERK信号通路具有抑制作用。 结论：在C2C12骨骼肌细胞和3T3-L1脂肪细胞中，大黄素能够上调糖代谢，减少脂解，还能抑制炎症。" @default.
• W1504653456 created "2016-06-24" @default.
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• W1504653456 date "2014-09-04" @default.
• W1504653456 modified "2023-10-12" @default.
• W1504653456 title "Emodin up-regulates glucose metabolism, decreases lipolysis, and attenuates inflammation in vitro大黄素在体内上调糖代谢、减少脂解和抑制炎症反应" @default.
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• W1504653456 doi "https://doi.org/10.1111/1753-0407.12190" @default.
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