Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504658722> ?p ?o ?g. }
- W1504658722 endingPage "1017" @default.
- W1504658722 startingPage "1009" @default.
- W1504658722 abstract "Neisseria gonorrhoeae is a human pathogen causing the sexually transmitted disease gonorrhoeae. The bacteria preferentially attach to and invade epithelial cells of the genital tract. As these cells previously have been shown to express the human cathelicidin LL-37, we wanted to investigate the role of LL-37 during N. gonorrhoeae infection. The cervical epithelial cell line ME180 was utilized and the expression of LL-37 was confirmed on both peptide and transcriptional levels. Moreover, LL-37 exhibited potent in vitro activity against N. gonorrhoeae. Interestingly, the transcript and peptide levels of LL-37 were downregulated during infection, according to quantitative real-time polymerase chain reaction (PCR) and immunocyto-chemistry. The downregulation was most prominent with pathogenic strains of Neisseria, while non-pathogenic strains such as Neisseria lactamica and Escherichia coli only exhibited moderate effects. Heat-killed N. gonorrhoeae had no impact on the downregulation, emphasizing the importance of live bacteria. The results in this study suggest that pathogenic Neisseria may gain a survival advantage in the female genital tract by downregulating LL-37 expression." @default.
- W1504658722 created "2016-06-24" @default.
- W1504658722 creator A5005179796 @default.
- W1504658722 creator A5023361814 @default.
- W1504658722 creator A5045938898 @default.
- W1504658722 creator A5048850866 @default.
- W1504658722 creator A5062170890 @default.
- W1504658722 creator A5063227388 @default.
- W1504658722 creator A5066012504 @default.
- W1504658722 date "2005-05-12" @default.
- W1504658722 modified "2023-10-11" @default.
- W1504658722 title "Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37" @default.
- W1504658722 cites W1500925296 @default.
- W1504658722 cites W1504680783 @default.
- W1504658722 cites W1532518718 @default.
- W1504658722 cites W1613038829 @default.
- W1504658722 cites W1941858237 @default.
- W1504658722 cites W1966640589 @default.
- W1504658722 cites W1975993749 @default.
- W1504658722 cites W1976891867 @default.
- W1504658722 cites W1977460176 @default.
- W1504658722 cites W1983987058 @default.
- W1504658722 cites W1984823135 @default.
- W1504658722 cites W1997065157 @default.
- W1504658722 cites W2012875995 @default.
- W1504658722 cites W2029331076 @default.
- W1504658722 cites W2040064814 @default.
- W1504658722 cites W2042116386 @default.
- W1504658722 cites W2045762865 @default.
- W1504658722 cites W2054602599 @default.
- W1504658722 cites W2057198053 @default.
- W1504658722 cites W2063495253 @default.
- W1504658722 cites W2063741440 @default.
- W1504658722 cites W2079637109 @default.
- W1504658722 cites W2090407536 @default.
- W1504658722 cites W2094036101 @default.
- W1504658722 cites W2109699279 @default.
- W1504658722 cites W2111719241 @default.
- W1504658722 cites W2113200077 @default.
- W1504658722 cites W2113556104 @default.
- W1504658722 cites W2126466156 @default.
- W1504658722 cites W2127449370 @default.
- W1504658722 cites W2130246343 @default.
- W1504658722 cites W2141391489 @default.
- W1504658722 cites W2147737222 @default.
- W1504658722 cites W2149811010 @default.
- W1504658722 cites W2159744947 @default.
- W1504658722 cites W2160043086 @default.
- W1504658722 cites W2161062368 @default.
- W1504658722 cites W2161215353 @default.
- W1504658722 cites W2164128280 @default.
- W1504658722 cites W2326930798 @default.
- W1504658722 cites W68983961 @default.
- W1504658722 doi "https://doi.org/10.1111/j.1462-5822.2005.00530.x" @default.
- W1504658722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15953032" @default.
- W1504658722 hasPublicationYear "2005" @default.
- W1504658722 type Work @default.
- W1504658722 sameAs 1504658722 @default.
- W1504658722 citedByCount "109" @default.
- W1504658722 countsByYear W15046587222012 @default.
- W1504658722 countsByYear W15046587222013 @default.
- W1504658722 countsByYear W15046587222014 @default.
- W1504658722 countsByYear W15046587222015 @default.
- W1504658722 countsByYear W15046587222016 @default.
- W1504658722 countsByYear W15046587222017 @default.
- W1504658722 countsByYear W15046587222018 @default.
- W1504658722 countsByYear W15046587222019 @default.
- W1504658722 countsByYear W15046587222020 @default.
- W1504658722 countsByYear W15046587222021 @default.
- W1504658722 countsByYear W15046587222022 @default.
- W1504658722 countsByYear W15046587222023 @default.
- W1504658722 crossrefType "journal-article" @default.
- W1504658722 hasAuthorship W1504658722A5005179796 @default.
- W1504658722 hasAuthorship W1504658722A5023361814 @default.
- W1504658722 hasAuthorship W1504658722A5045938898 @default.
- W1504658722 hasAuthorship W1504658722A5048850866 @default.
- W1504658722 hasAuthorship W1504658722A5062170890 @default.
- W1504658722 hasAuthorship W1504658722A5063227388 @default.
- W1504658722 hasAuthorship W1504658722A5066012504 @default.
- W1504658722 hasBestOaLocation W15046587221 @default.
- W1504658722 hasConcept C104317684 @default.
- W1504658722 hasConcept C127561419 @default.
- W1504658722 hasConcept C159047783 @default.
- W1504658722 hasConcept C2776460866 @default.
- W1504658722 hasConcept C2776983459 @default.
- W1504658722 hasConcept C2777379352 @default.
- W1504658722 hasConcept C2777954195 @default.
- W1504658722 hasConcept C2779166590 @default.
- W1504658722 hasConcept C2909760446 @default.
- W1504658722 hasConcept C3013748606 @default.
- W1504658722 hasConcept C4937899 @default.
- W1504658722 hasConcept C523546767 @default.
- W1504658722 hasConcept C540938839 @default.
- W1504658722 hasConcept C54355233 @default.
- W1504658722 hasConcept C86803240 @default.
- W1504658722 hasConcept C89423630 @default.
- W1504658722 hasConceptScore W1504658722C104317684 @default.
- W1504658722 hasConceptScore W1504658722C127561419 @default.