Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504702309> ?p ?o ?g. }
- W1504702309 abstract "Melanoma is one of the most deadly forms of skin cancer. The incidence of melanoma has been steadily increasing over the last several decades. It is estimated that in 2010 68,130 adults were diagnosed with melanoma, and 8,700 patients died of this disease (Jemal et al.). Melanoma is highly curable when it is diagnosed at early stages. However, patients with distant metastases have a median overall survival of only 6-8 months (Balch et al. 2009). Chemotherapy regimens have not improved survival in patients with metastatic melanoma, and immunotherapies have generally benefited only a small percentage of patients (Koon and Atkins 2006). Thus, there is a critical need to develop more effective therapeutic approaches for this disease. Recently, dramatic results have been reported with agents that specifically target proteins or pathways that are aberrant in this disease, such as BRAF and c-KIT (Flaherty et al. ; Hodi et al. 2008). These results support the rationale for continued investigation into the molecular events that characterize and contribute to melanoma. This review will describe existing knowledge about several of the molecules and pathways that have been implicated in melanoma, and review the results of clinical studies focused on these targets." @default.
- W1504702309 created "2016-06-24" @default.
- W1504702309 creator A5021521263 @default.
- W1504702309 creator A5048327749 @default.
- W1504702309 date "2011-09-12" @default.
- W1504702309 modified "2023-10-17" @default.
- W1504702309 title "New Molecular Targets for the Systemic Therapy of Melanoma" @default.
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