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- W1504801249 abstract "Treating pancreatic cancer is one of the great challenges in cancer research and identification of new strategies is a must, considering the poor efficiency of standard chemotherapy and current patients’ dismal prognosis. We have recently identified Galectin-1 as a master regulator driving pancreatic cancer progression in the Ela-myc model. Interestingly, Galectin-1 depletion in these tumors not only results in decreased tumor cell proliferation but also in a profound remodeling of the desmoplastic reaction, impairing angiogenesis, stroma activation and boosting the animal immune response. Intriguingly, our experimental data indicate that Galectin-1 regulates the Hedgehog signaling pathway, which may well be responsible for some of the effects driven by the lectin in pancreatic cancer. We herein discuss how Galectin-1 may remodel the tumor microenvironment in this pathology and highlight its potential as a therapeutic target." @default.
- W1504801249 created "2016-06-24" @default.
- W1504801249 creator A5039737999 @default.
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- W1504801249 date "2014-09-27" @default.
- W1504801249 modified "2023-10-06" @default.
- W1504801249 title "Galectin-1 as a therapeutic target in pancreatic cancer: the tumor stroma in the spotlight" @default.
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- W1504801249 doi "https://doi.org/10.14800/ccm.296" @default.
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