FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504906459> ?p ?o ?g. }

• W1504906459 endingPage "659" @default.
• W1504906459 startingPage "654" @default.
• W1504906459 abstract "Rapamycin has long been considered an immunosuppressive agent due to its antiproliferative effects on immune cells, and is currently used as a component of antirejection regimens in transplantation. Despite the large number of mechanistic and clinical studies investigating the impact of rapamycin on cell-mediated immunity, several paradoxes concerning rapamycin immunobiology remain. In particular, emerging evidence suggests that under certain circumstances rapamycin can exert immunostimulatory effects, boosting T cell responses in the face of pathogen infections and vaccines. Here, we review recent findings concerning the contradictory outcomes of rapamycin induced mTOR inhibition on CD4(+) and CD8(+) T cell responses in transplantation and protective immunity. These studies suggest that the conditions under which T cells are stimulated can profoundly modify the impact of rapamycin on antigen-specific T cell responses. Thus, further investigation into the cellular and molecular pathways underlying the dichotomous effects of rapamycin in transplantation is required to harness the full potential of this immunomodulatory agent to promote graft survival and maximize protective immunity." @default.
• W1504906459 created "2016-06-24" @default.
• W1504906459 creator A5038996345 @default.
• W1504906459 creator A5057639297 @default.
• W1504906459 creator A5087476769 @default.
• W1504906459 date "2011-04-01" @default.
• W1504906459 modified "2023-09-23" @default.
• W1504906459 title "Paradoxical Aspects of Rapamycin Immunobiology in Transplantation" @default.
• W1504906459 cites W1532778742 @default.
• W1504906459 cites W1820532154 @default.
• W1504906459 cites W1903749320 @default.
• W1504906459 cites W1965335458 @default.
• W1504906459 cites W1971278669 @default.
• W1504906459 cites W1973314755 @default.
• W1504906459 cites W1983458614 @default.
• W1504906459 cites W1984110560 @default.
• W1504906459 cites W1999324987 @default.
• W1504906459 cites W2008686731 @default.
• W1504906459 cites W2010498205 @default.
• W1504906459 cites W2010665897 @default.
• W1504906459 cites W2018066433 @default.
• W1504906459 cites W2035557966 @default.
• W1504906459 cites W2048376025 @default.
• W1504906459 cites W2055280546 @default.
• W1504906459 cites W2056721231 @default.
• W1504906459 cites W2059689009 @default.
• W1504906459 cites W2064876347 @default.
• W1504906459 cites W2076125315 @default.
• W1504906459 cites W2076628707 @default.
• W1504906459 cites W2089887386 @default.
• W1504906459 cites W2090648684 @default.
• W1504906459 cites W2100714842 @default.
• W1504906459 cites W2136339350 @default.
• W1504906459 cites W2146409195 @default.
• W1504906459 cites W2146652028 @default.
• W1504906459 cites W2149142511 @default.
• W1504906459 cites W2152600551 @default.
• W1504906459 cites W2163502830 @default.
• W1504906459 cites W4242872472 @default.
• W1504906459 cites W4313422306 @default.
• W1504906459 doi "https://doi.org/10.1111/j.1600-6143.2011.03473.x" @default.
• W1504906459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3685502" @default.
• W1504906459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21446969" @default.
• W1504906459 hasPublicationYear "2011" @default.
• W1504906459 type Work @default.
• W1504906459 sameAs 1504906459 @default.
• W1504906459 citedByCount "61" @default.
• W1504906459 countsByYear W15049064592012 @default.
• W1504906459 countsByYear W15049064592013 @default.
• W1504906459 countsByYear W15049064592014 @default.
• W1504906459 countsByYear W15049064592015 @default.
• W1504906459 countsByYear W15049064592016 @default.
• W1504906459 countsByYear W15049064592017 @default.
• W1504906459 countsByYear W15049064592018 @default.
• W1504906459 countsByYear W15049064592019 @default.
• W1504906459 countsByYear W15049064592020 @default.
• W1504906459 countsByYear W15049064592021 @default.
• W1504906459 countsByYear W15049064592022 @default.
• W1504906459 crossrefType "journal-article" @default.
• W1504906459 hasAuthorship W1504906459A5038996345 @default.
• W1504906459 hasAuthorship W1504906459A5057639297 @default.
• W1504906459 hasAuthorship W1504906459A5087476769 @default.
• W1504906459 hasBestOaLocation W15049064592 @default.
• W1504906459 hasConcept C126322002 @default.
• W1504906459 hasConcept C167672396 @default.
• W1504906459 hasConcept C193419808 @default.
• W1504906459 hasConcept C203014093 @default.
• W1504906459 hasConcept C2776090121 @default.
• W1504906459 hasConcept C2777921159 @default.
• W1504906459 hasConcept C2779341262 @default.
• W1504906459 hasConcept C2780179540 @default.
• W1504906459 hasConcept C2911091166 @default.
• W1504906459 hasConcept C62478195 @default.
• W1504906459 hasConcept C71924100 @default.
• W1504906459 hasConcept C86554907 @default.
• W1504906459 hasConcept C86803240 @default.
• W1504906459 hasConcept C8891405 @default.
• W1504906459 hasConcept C95444343 @default.
• W1504906459 hasConceptScore W1504906459C126322002 @default.
• W1504906459 hasConceptScore W1504906459C167672396 @default.
• W1504906459 hasConceptScore W1504906459C193419808 @default.
• W1504906459 hasConceptScore W1504906459C203014093 @default.
• W1504906459 hasConceptScore W1504906459C2776090121 @default.
• W1504906459 hasConceptScore W1504906459C2777921159 @default.
• W1504906459 hasConceptScore W1504906459C2779341262 @default.
• W1504906459 hasConceptScore W1504906459C2780179540 @default.
• W1504906459 hasConceptScore W1504906459C2911091166 @default.
• W1504906459 hasConceptScore W1504906459C62478195 @default.
• W1504906459 hasConceptScore W1504906459C71924100 @default.
• W1504906459 hasConceptScore W1504906459C86554907 @default.
• W1504906459 hasConceptScore W1504906459C86803240 @default.
• W1504906459 hasConceptScore W1504906459C8891405 @default.
• W1504906459 hasConceptScore W1504906459C95444343 @default.
• W1504906459 hasIssue "4" @default.
• W1504906459 hasLocation W15049064591 @default.
• W1504906459 hasLocation W15049064592 @default.
• W1504906459 hasLocation W15049064593 @default.
• W1504906459 hasLocation W15049064594 @default.

• next