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- W1504920005 abstract "Malignant glioma (MG) is the most common type of malignant tumors derived from neuroepithelial tissue, and accounts for 46% of brain tumors. It has an incidence of 30100/million and ranks third in adult mortality and second in child mortality in all cancer patients. Compared with malignant tumors from other tissues and organs, MG has much lower treatment success rates. Despite global efforts over the past thirty years, there has been no major breakthrough in treatment and patient survival has not significantly improved. The median survival time after diagnosis is eight months in patients receiving surgery alone and 11 months in patients receiving surgery plus adjuvant radiotherapy/chemotherapy. Conventional treatments for MG include surgical resection, adjuvant whole brain radiotherapy (WBRT), and systemic chemotherapy. Limitations of these treatments include: 1. Surgical resection: MG is highly invasive. As a result, total resection is typically not achieved in surgery. The operation may also activate residual tumor cells from the G0 phase to the proliferation phase, resulting in tumor recurrence of malignancy. 2. Post-operative WBRT. The effective dose for MG (73-80 Gy) is higher than the maximum tolerated dose for brain tissue (60 Gy). The therapeutic effects at a dose of 60 Gy are mediated primarily by radioactive ions that stimulate endotheliocytosis in the microvascular bed of the tumor. The endotheliocytosis results in embolism and decreased blood supply to tumor. 3. Post-operative chemotherapy. Upon systemic treatment, only ~20% of chemotherapeutic agents reach the brain. The blood brain barrier (BBB) around the post-operative tumor cavity also prevents the chemotherapeutic agents from reaching the site of action. The weak immunogenicity of the glioma membrane and the heterogeneity of the cells have limited the application of immunotherapy. The unique biological properties and lack of effective clinical treatment creates a challenge for clinical practice and basic experimental research [1,2]." @default.
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- W1504920005 date "2011-09-22" @default.
- W1504920005 modified "2023-09-25" @default.
- W1504920005 title "Regional Chemotherapy and Brachytherapy for Malignant Glioma – Clinical Experience and Serial Experiments" @default.
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- W1504920005 doi "https://doi.org/10.5772/23543" @default.
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