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- W1504920623 abstract "Abstract IL-17 and its receptor are founding members of a novel inflammatory cytokine family. To date, only one IL-17 receptor subunit has been identified, termed IL-17RA. All known cytokine receptors consist of a complex of multiple subunits. Although IL-17-family cytokines exist as homodimers, the configuration and stoichiometry of the IL-17R complex remain unknown. We used fluorescence resonance energy transfer (FRET) to determine whether IL-17RA subunits multimerize, and, if so, whether they are preassembled in the plasma membrane. HEK293 cells coexpressing IL-17RA fused to cyan or yellow fluorescent proteins (CFP or YFP) were used to evaluate FRET before and after IL-17A or IL-17F treatment. In the absence of ligand, IL-17RA molecules exhibited significant specific FRET efficiency, demonstrating that they exist in a multimeric, preformed receptor complex. Strikingly, treatment with IL-17A or IL-17F markedly reduced FRET efficiency, suggesting that IL-17RA subunits within the IL-17R complex undergo a conformational change upon ligand binding." @default.
- W1504920623 created "2016-06-24" @default.
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- W1504920623 date "2006-01-15" @default.
- W1504920623 modified "2023-10-14" @default.
- W1504920623 title "Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor" @default.
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- W1504920623 doi "https://doi.org/10.4049/jimmunol.176.2.711" @default.
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