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- W1504966336 abstract "청미래덩굴 추출물의 주름개선 효과를 확인하기 위해 elastase 저해활성을 측정한 결과 청미래덩굴 에탄올 추출물과 열수 추출물이 <TEX>$1,000{mu}g/ml$</TEX>에서 각각 41.1%, 16.3%의 활성을 나타내었으며, collagenase 저해활성 측정결과 청미래덩굴 에탄올 추출물과 열수 추출물이 <TEX>$1,000{mu}g/ml$</TEX>에서 각각 96.6%, 60.0%의 활성을 나타내었다. 청미래덩굴의 에탄올 추출물의 세포생존율을 확인하기 위하여 섬유아세포(CCD-986sk)로 MTT assay에 의해 확인한 결과 <TEX>$50{mu</TEX><TEX>}g/ml$</TEX> 농도에서 71.7%의 세포 생존율을 확인할 수 있었다. 섬유아 세포에서 청미래덩굴 에탄올 추출물의 pro-collagen type-1 생합성량을 확인한 결과 <TEX>$50{mu}g/ml$</TEX>의 농도에서 139% 이상의 우수한 효과를 나타내었으며, MMP-1 저해활성을 측정한 결과 <TEX>$50{mu}g/ml$</TEX>의 각각의 농도에서 74.9%의 활성을 나타내었다. 청미래덩굴 에탄올 추출물을 처리한 섬유아 세포에서 MMP family 중 MMP-1의 단백질 발현 및 mRNA 발현 억제 효과를 확인한 결과 MMP-1 단백질 발현과 mRNA 발현 모두 <TEX>$50{mu}g/ml$</TEX>에서 각각 35%, 45%의 저해율을 나타내었다. 이러한 결과로 미루어 보아 청미래덩굴 에탄올 추출물이 주름개선용 화장품 소재로 응용이 가능할 것으로 판단된다. The purpose of this study was to research the biological activity of ethanol extract from Smilax china L. which is a vine shrub belonging to the lily family. For antiwrinkle effects, elastase inhibition effect of ethanol and water extracts from S. china L. showed 41.1% and 16.3% at <TEX>$1,000{mu}g/ml$</TEX> concentration. The collagenase inhibition effect of ethanol and water extracts from S. china L. showed more than 96.6% and 60.0% at <TEX>$1,000{mu}g/ml$</TEX> concentration. As a result of having fibroblast measured cell viability on fibroblast cell of ethanol extract from S. china L., it showed 71.7% with cell viability at <TEX>$100{mu}g/ml$</TEX> concentration. At <TEX>$50{mu}g/ml$</TEX> concentration, the procollagen biosynthesis effect of ethanol extract from S. china L. was 139.86%. At the same concentration, the matrix metalloprotease (MMP)-1 inhibition effect of the ethanol extract was 74.9%. According to the results of Western blot of ethanol extract from S. china L., the expression of the MMP-1 protein was decreased by 35% at <TEX>$50{mu}g/ml$</TEX> concentration. Reverse transcription-polymerase chain reaction (PCR) of ethanol extract from S. china L. showed that the expression of MMP-1 mRNA was decreased by 45% at <TEX>$50{mu}g/ml$</TEX> concentration. The findings suggest that 70% ethanol extract from S. china L. (SC) has great potential as a cosmeceutical ingredient with antiwrinkle effects." @default.
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- W1504966336 date "2013-10-30" @default.
- W1504966336 modified "2023-10-17" @default.
- W1504966336 title "Inhibitory Efficacy of Smilax china L. on Pro-collagen Type-1 Activity and MMP-1 Gene Expression in Fibroblasts (CCD-986sk)" @default.
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- W1504966336 doi "https://doi.org/10.5352/jls.2013.23.10.1239" @default.
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