Matches in SemOpenAlex for { <https://semopenalex.org/work/W150496735> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W150496735 endingPage "4" @default.
- W150496735 startingPage "541" @default.
- W150496735 abstract "Affinity maturation was studied by the analysis of the kinetics of the appearance of antibody subpopulations with different affinities during the immune response, using an hapten-inhibition ELISA. The immune response in KLH-Ar-immunized A/J mice was used as a model system. Five antibody subpopulations of different affinity (10(3)-10(7) M-1) could be detected, the relative concentrations of which changed during affinity maturation. The high-affinity antibody subpopulations did not represent the major fraction at any stage during affinity maturation. The appearance of the highest affinity subpopulation (10(7) M-1), despite exhibiting relative concentrations no higher than 12%, produced an important increase in average affinity. On the other hand, its disappearance at the end of the maturation process could explain the average affinity decrease observed at this stage. Our results indicate that affinity maturation cannot be explained by the dominance of high-affinity clones, as proposed by Siskind & Benacerraf (1969). The increase in affinity could rather be due to the progressive appearance of low percentages of high-affinity clones, which are not present in the primary response and never become dominant." @default.
- W150496735 created "2016-06-24" @default.
- W150496735 creator A5055595964 @default.
- W150496735 creator A5062895945 @default.
- W150496735 creator A5079673485 @default.
- W150496735 creator A5082131943 @default.
- W150496735 date "1986-08-01" @default.
- W150496735 modified "2023-10-17" @default.
- W150496735 title "Affinity maturation in the arsonate system: lack of dominance of high-affinity antibody subpopulations." @default.
- W150496735 cites W103355151 @default.
- W150496735 cites W1562668221 @default.
- W150496735 cites W1834379353 @default.
- W150496735 cites W1933203885 @default.
- W150496735 cites W1963584668 @default.
- W150496735 cites W1990646462 @default.
- W150496735 cites W2004303268 @default.
- W150496735 cites W2032381660 @default.
- W150496735 cites W2058638844 @default.
- W150496735 cites W2058709384 @default.
- W150496735 cites W2059275484 @default.
- W150496735 cites W2068747743 @default.
- W150496735 cites W2069323100 @default.
- W150496735 cites W2083740767 @default.
- W150496735 cites W2083925503 @default.
- W150496735 cites W2153593191 @default.
- W150496735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1453110" @default.
- W150496735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3733154" @default.
- W150496735 hasPublicationYear "1986" @default.
- W150496735 type Work @default.
- W150496735 sameAs 150496735 @default.
- W150496735 citedByCount "4" @default.
- W150496735 crossrefType "journal-article" @default.
- W150496735 hasAuthorship W150496735A5055595964 @default.
- W150496735 hasAuthorship W150496735A5062895945 @default.
- W150496735 hasAuthorship W150496735A5079673485 @default.
- W150496735 hasAuthorship W150496735A5082131943 @default.
- W150496735 hasConcept C104317684 @default.
- W150496735 hasConcept C121332964 @default.
- W150496735 hasConcept C148898269 @default.
- W150496735 hasConcept C151913843 @default.
- W150496735 hasConcept C153911025 @default.
- W150496735 hasConcept C159654299 @default.
- W150496735 hasConcept C179247698 @default.
- W150496735 hasConcept C181199279 @default.
- W150496735 hasConcept C185592680 @default.
- W150496735 hasConcept C203014093 @default.
- W150496735 hasConcept C2780283098 @default.
- W150496735 hasConcept C2781377902 @default.
- W150496735 hasConcept C29144244 @default.
- W150496735 hasConcept C55493867 @default.
- W150496735 hasConcept C62520636 @default.
- W150496735 hasConcept C86803240 @default.
- W150496735 hasConcept C8891405 @default.
- W150496735 hasConceptScore W150496735C104317684 @default.
- W150496735 hasConceptScore W150496735C121332964 @default.
- W150496735 hasConceptScore W150496735C148898269 @default.
- W150496735 hasConceptScore W150496735C151913843 @default.
- W150496735 hasConceptScore W150496735C153911025 @default.
- W150496735 hasConceptScore W150496735C159654299 @default.
- W150496735 hasConceptScore W150496735C179247698 @default.
- W150496735 hasConceptScore W150496735C181199279 @default.
- W150496735 hasConceptScore W150496735C185592680 @default.
- W150496735 hasConceptScore W150496735C203014093 @default.
- W150496735 hasConceptScore W150496735C2780283098 @default.
- W150496735 hasConceptScore W150496735C2781377902 @default.
- W150496735 hasConceptScore W150496735C29144244 @default.
- W150496735 hasConceptScore W150496735C55493867 @default.
- W150496735 hasConceptScore W150496735C62520636 @default.
- W150496735 hasConceptScore W150496735C86803240 @default.
- W150496735 hasConceptScore W150496735C8891405 @default.
- W150496735 hasIssue "4" @default.
- W150496735 hasLocation W1504967351 @default.
- W150496735 hasOpenAccess W150496735 @default.
- W150496735 hasPrimaryLocation W1504967351 @default.
- W150496735 hasRelatedWork W150496735 @default.
- W150496735 hasRelatedWork W1530462788 @default.
- W150496735 hasRelatedWork W1536009741 @default.
- W150496735 hasRelatedWork W1832127051 @default.
- W150496735 hasRelatedWork W2032040026 @default.
- W150496735 hasRelatedWork W2043952704 @default.
- W150496735 hasRelatedWork W2070361312 @default.
- W150496735 hasRelatedWork W2147684578 @default.
- W150496735 hasRelatedWork W2195872516 @default.
- W150496735 hasRelatedWork W4290014404 @default.
- W150496735 hasVolume "58" @default.
- W150496735 isParatext "false" @default.
- W150496735 isRetracted "false" @default.
- W150496735 magId "150496735" @default.
- W150496735 workType "article" @default.