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• W1505159144 abstract "Disrupted morphogenesis and growth of the embryonic maxillary jaw lead to oral facial clefting in humans (OFC) and result in an incompletely formed secondary mouth and face. A requirement for Wnt signaling and Wnt9b in particular are postulated in the etiology of OFC from association studies in humans and from animal models. Loss of murine Wnt9b leads to reduced upper jaw (maxillary) outgrowth and OFC, though the signaling architecture leading to this phenotype is poorly understood. Previous murine Wnt9b studies largely overlooked cranial neural crest cell (CNCC) patterning events and instead focused on later events during fusion of facial prominences. Using zebrafish and a morpholino-mediated knockdown approach, we demonstrate functional requirements for Wnt9b signaling during two crucial stages of facial development: 1) CNCC patterning into Dorsal-Intermediate-Ventral (D-I-V) domains; and 2) facial outgrowth during the primary to secondary mouth transition (PM to SM). Zebrafish embryos deficient for Wnt9b (Wnt9b morphants) exhibit an open bite with fused jaw joints as well as a flat face. Open bite and jaw joint fusion in Wnt9b morphants phenocopies characteristics of edn1 pathway is mutant zebrafish with disrupted D-I-V patterning of CNCC. Expression studies show Wnt9b morphants exhibit perturbed expression of edn1 signaling targets including dlx2a, jag1b, and msxe, consistent with disrupted CNCC patterning. Wnt9b morphant upper jaws have stunted outgrowth reminiscent of murine Wnt9b mutants and Wnt9b morphant skulls phenocopy the broad class of foreshortened skull zebrafish mutants known as hammerheads. Wnt9b morphants show upregulated expression of pitx2a after the opening of the primary mouth and disrupted expression of Wnt5b which is consistent with disrupted chondrocyte stacking. Strong upregulation of dorsal mesodermal frzb expression in the prechordal plate of Wnt9b morphants suggests a role for Wnt9b in primary mouth induction or maintenance. Collectively these results argue that Wnt9b has a much earlier developmental requirement. This work draws attention to potential vertebrate homologies that pattern CNCC and facial outgrowth and therefore calls for a reexamination of Wnt9b’s role during mammalian craniofacial development." @default.
• W1505159144 created "2016-06-24" @default.
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• W1505159144 date "2015-01-01" @default.
• W1505159144 modified "2023-10-06" @default.
• W1505159144 title "Zebrafish Wnt9b Patterns the First Pharyngeal Arch into D-I-V Domains and Promotes Anterior-Medial Outgrowth" @default.
• W1505159144 cites W1500223252 @default.
• W1505159144 cites W1823132102 @default.
• W1505159144 cites W1932141264 @default.
• W1505159144 cites W1963565699 @default.
• W1505159144 cites W1966713142 @default.
• W1505159144 cites W1968298199 @default.
• W1505159144 cites W1976781470 @default.
• W1505159144 cites W1978868065 @default.
• W1505159144 cites W1992109292 @default.
• W1505159144 cites W2007532597 @default.
• W1505159144 cites W2009089343 @default.
• W1505159144 cites W2009382384 @default.
• W1505159144 cites W2016620270 @default.
• W1505159144 cites W2018527359 @default.
• W1505159144 cites W2018725502 @default.
• W1505159144 cites W2022830639 @default.
• W1505159144 cites W2022906661 @default.
• W1505159144 cites W2030792858 @default.
• W1505159144 cites W2036185266 @default.
• W1505159144 cites W2036211290 @default.
• W1505159144 cites W2036236969 @default.
• W1505159144 cites W2041898473 @default.
• W1505159144 cites W2042471624 @default.
• W1505159144 cites W2042812406 @default.
• W1505159144 cites W2044848239 @default.
• W1505159144 cites W2045865999 @default.
• W1505159144 cites W2046340131 @default.
• W1505159144 cites W2046808794 @default.
• W1505159144 cites W2047954622 @default.
• W1505159144 cites W2053060034 @default.
• W1505159144 cites W2053188090 @default.
• W1505159144 cites W2056434612 @default.
• W1505159144 cites W2056662897 @default.
• W1505159144 cites W2059032864 @default.
• W1505159144 cites W2062722583 @default.
• W1505159144 cites W2064239281 @default.
• W1505159144 cites W2070270500 @default.
• W1505159144 cites W2070738391 @default.
• W1505159144 cites W2072016374 @default.
• W1505159144 cites W2074505709 @default.
• W1505159144 cites W2078430222 @default.
• W1505159144 cites W2079432590 @default.
• W1505159144 cites W2084074518 @default.
• W1505159144 cites W2084341282 @default.
• W1505159144 cites W2086998851 @default.
• W1505159144 cites W2090020776 @default.
• W1505159144 cites W2090164402 @default.
• W1505159144 cites W2096060803 @default.
• W1505159144 cites W2097672164 @default.
• W1505159144 cites W2100004497 @default.
• W1505159144 cites W2100468441 @default.
• W1505159144 cites W2102681710 @default.
• W1505159144 cites W2105419834 @default.
• W1505159144 cites W2108274213 @default.
• W1505159144 cites W2126629482 @default.
• W1505159144 cites W2127916890 @default.
• W1505159144 cites W2132225262 @default.
• W1505159144 cites W2135460062 @default.
• W1505159144 cites W2137231843 @default.
• W1505159144 cites W2139231790 @default.
• W1505159144 cites W2144519600 @default.
• W1505159144 cites W2148178820 @default.
• W1505159144 cites W2156661766 @default.
• W1505159144 cites W2156936497 @default.
• W1505159144 cites W2158747582 @default.
• W1505159144 cites W2159996969 @default.
• W1505159144 cites W2163540883 @default.
• W1505159144 cites W2167627426 @default.
• W1505159144 cites W2168348494 @default.
• W1505159144 cites W2169531249 @default.
• W1505159144 cites W2172122920 @default.
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• W1505159144 doi "https://doi.org/10.4236/ajmb.2015.53006" @default.
• W1505159144 hasPublicationYear "2015" @default.
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