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- W150520902 abstract "Interaction between a toxic agent and an organism is a two-way process; both toxin and organism play a role in the final outcome of toxicity. This chapter reviews the biochemical basis for toxicologic interactions. It aims to: (1) define the effect that the organism has on the compound, in terms of absorption, distribution, metabolism, and excretion; (2) define the initial effect that the toxic agent has on the organism in terms of interacting with specific sites or nonspecific sites (membranes, protein, and so forth); (3) identify factors that cause variation in these events; and (4) summarize the biochemical events that follow the initial insult, frequently preceding detectable morphologic change. The site of toxicity of a xenobiotic is strongly dependent on its distribution. The pulmonary toxicant paraquat concentrates in the lung, whereas its analog diquat concentrates in the liver and is hepatotoxic. This chapter concludes the fundamental principle of both pharmacology and toxicology that is the action or effect is proportional to the dose reaching the site of action. This dose-response relationship applies both to the individual and to the population." @default.
- W150520902 created "2016-06-24" @default.
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- W150520902 date "2002-01-01" @default.
- W150520902 modified "2023-09-26" @default.
- W150520902 title "Biochemical Basis of Toxicity" @default.
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- W150520902 doi "https://doi.org/10.1016/b978-012330215-1/50003-x" @default.
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