Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505267416> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1505267416 endingPage "214" @default.
- W1505267416 startingPage "208" @default.
- W1505267416 abstract "OBJECTIVES The aim of the study is to investigate the modulatory effects of dietary supplementation of N-acetyl-L-cysteine (NAC) on glutathione (GSH) concentration in liver and lung, and lipid peroxidation in cigarette smoke-exposed rats fed a low-protein diet. METHODS Rats were divided randomly into 4 dietary groups; 8 per group. The control group (Group 1) was fed a normal-protein diet and received room air as a sham-smoke exposure. Group 2 was fed a normal-protein diet, Group 3 was fed with a low-protein diet and Group 4 was fed with a low-protein diet supplemented with NAC, and exposed to the smoke of 10 cigarettes/hour/day until the end of the experiment (4 weeks) period. Glutathione in liver and lung and serum albumin level were measured. Also, thiobarbituric acid reactive substances (TBARS) were measured, as an indication of oxidative stress. The study was conducted in the College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia, in the year 2003. RESULTS Smoke-exposed rats fed with the low-protein diet had significantly lower hepatic GSH concentration compared to other dietary groups. Moreover, NAC supplementation to the low-protein diet, in the smoke-exposed rats, significantly increased hepatic GSH concentration compared to the corresponding animals fed the same amount of protein, but without NAC supplementation. No reduction in lung GSH concentration occurred in cigarette-smoke rats fed a low-protein diet supplemented with NAC. Cigarette smoking significantly increased the level of TBARS in serum in all dietary groups compared to the control. However, the elevation in the TBARS level was higher in the low protein dietary group. CONCLUSIONS The results show no significant reduction in the lung and hepatic GSH concentration in cigarette smoke-exposed rats fed a normal-protein diet compared with the corresponding control rats fed a same level of protein. The study indicates the efficiency of NAC supplementation in scavenging free-radicals and enhancing GSH concentration in smoke-exposed rats fed a low-protein diet." @default.
- W1505267416 created "2016-06-24" @default.
- W1505267416 creator A5078280907 @default.
- W1505267416 date "2005-02-01" @default.
- W1505267416 modified "2023-09-22" @default.
- W1505267416 title "The effect of dietary supplementation of N-acetyl-L-cysteine on glutathione concentration and lipid peroxidation in cigarette smoke-exposed rats fed a low-protein diet." @default.
- W1505267416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15770292" @default.
- W1505267416 hasPublicationYear "2005" @default.
- W1505267416 type Work @default.
- W1505267416 sameAs 1505267416 @default.
- W1505267416 citedByCount "3" @default.
- W1505267416 countsByYear W15052674162018 @default.
- W1505267416 crossrefType "journal-article" @default.
- W1505267416 hasAuthorship W1505267416A5078280907 @default.
- W1505267416 hasConcept C126322002 @default.
- W1505267416 hasConcept C134018914 @default.
- W1505267416 hasConcept C181199279 @default.
- W1505267416 hasConcept C185592680 @default.
- W1505267416 hasConcept C2776151105 @default.
- W1505267416 hasConcept C2777352226 @default.
- W1505267416 hasConcept C2777504301 @default.
- W1505267416 hasConcept C2777661713 @default.
- W1505267416 hasConcept C2778004101 @default.
- W1505267416 hasConcept C2780829032 @default.
- W1505267416 hasConcept C538909803 @default.
- W1505267416 hasConcept C55493867 @default.
- W1505267416 hasConcept C71924100 @default.
- W1505267416 hasConceptScore W1505267416C126322002 @default.
- W1505267416 hasConceptScore W1505267416C134018914 @default.
- W1505267416 hasConceptScore W1505267416C181199279 @default.
- W1505267416 hasConceptScore W1505267416C185592680 @default.
- W1505267416 hasConceptScore W1505267416C2776151105 @default.
- W1505267416 hasConceptScore W1505267416C2777352226 @default.
- W1505267416 hasConceptScore W1505267416C2777504301 @default.
- W1505267416 hasConceptScore W1505267416C2777661713 @default.
- W1505267416 hasConceptScore W1505267416C2778004101 @default.
- W1505267416 hasConceptScore W1505267416C2780829032 @default.
- W1505267416 hasConceptScore W1505267416C538909803 @default.
- W1505267416 hasConceptScore W1505267416C55493867 @default.
- W1505267416 hasConceptScore W1505267416C71924100 @default.
- W1505267416 hasIssue "2" @default.
- W1505267416 hasLocation W15052674161 @default.
- W1505267416 hasLocation W15052674162 @default.
- W1505267416 hasOpenAccess W1505267416 @default.
- W1505267416 hasPrimaryLocation W15052674161 @default.
- W1505267416 hasRelatedWork W1685203226 @default.
- W1505267416 hasRelatedWork W1963689553 @default.
- W1505267416 hasRelatedWork W1998213837 @default.
- W1505267416 hasRelatedWork W2002240157 @default.
- W1505267416 hasRelatedWork W2074424446 @default.
- W1505267416 hasRelatedWork W2079961975 @default.
- W1505267416 hasRelatedWork W2085064018 @default.
- W1505267416 hasRelatedWork W2112614100 @default.
- W1505267416 hasRelatedWork W2131515497 @default.
- W1505267416 hasRelatedWork W2133432414 @default.
- W1505267416 hasRelatedWork W2347705864 @default.
- W1505267416 hasRelatedWork W2364143519 @default.
- W1505267416 hasRelatedWork W2365417028 @default.
- W1505267416 hasRelatedWork W2399702594 @default.
- W1505267416 hasRelatedWork W2417345095 @default.
- W1505267416 hasRelatedWork W2604045655 @default.
- W1505267416 hasRelatedWork W2746976463 @default.
- W1505267416 hasRelatedWork W2765009781 @default.
- W1505267416 hasRelatedWork W878602680 @default.
- W1505267416 hasRelatedWork W2340763564 @default.
- W1505267416 hasVolume "26" @default.
- W1505267416 isParatext "false" @default.
- W1505267416 isRetracted "false" @default.
- W1505267416 magId "1505267416" @default.
- W1505267416 workType "article" @default.