Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505278832> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1505278832 endingPage "5" @default.
- W1505278832 startingPage "213" @default.
- W1505278832 abstract "Cell proliferation is a complex and important event in atherosclerosis, aging and cancer, and is under the control of signalling pathways. These signalling pathways in turn are effected by the presence of a number of chemicals. For this purpose, we have checked the effect of two chemicals on the proliferation of skin fibroblasts. alpha-Tocopherol and silibin dihemisuccinate (SDH) negatively regulate proliferation of human skin fibroblasts. To check the cell-cycle time intervals, a [3H]thymidine incorporation assay was performed, showing DNA replication at around 24 h; this indicated the time required for the incubation with the chemicals. When alpha-tocopherol was added to the growth medium at a physiological concentration of 50 microM, cell proliferation was inhibited by 40% in 72 h. A similar inhibitory effect of cell proliferation was achieved when 500 microM SDH was used (39% inhibition in 72 h). From the dose-response curves obtained it was concluded that both duration of treatment and the concentration of the chemicals are important parameters. The actual mechanism of the inhibition of cell proliferation may be due to the anti-oxidative potential of these chemicals as well as another mechanism effecting signal transduction pathways." @default.
- W1505278832 created "2016-06-24" @default.
- W1505278832 creator A5028118284 @default.
- W1505278832 creator A5042840198 @default.
- W1505278832 creator A5063234373 @default.
- W1505278832 creator A5068237304 @default.
- W1505278832 date "1999-06-01" @default.
- W1505278832 modified "2023-09-23" @default.
- W1505278832 title "Effect of alpha-tocopherol and silibin dihemisuccinate on the proliferation of human skin fibroblasts." @default.
- W1505278832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10334950" @default.
- W1505278832 hasPublicationYear "1999" @default.
- W1505278832 type Work @default.
- W1505278832 sameAs 1505278832 @default.
- W1505278832 citedByCount "6" @default.
- W1505278832 countsByYear W15052788322017 @default.
- W1505278832 crossrefType "journal-article" @default.
- W1505278832 hasAuthorship W1505278832A5028118284 @default.
- W1505278832 hasAuthorship W1505278832A5042840198 @default.
- W1505278832 hasAuthorship W1505278832A5063234373 @default.
- W1505278832 hasAuthorship W1505278832A5068237304 @default.
- W1505278832 hasConcept C1491633281 @default.
- W1505278832 hasConcept C153911025 @default.
- W1505278832 hasConcept C185592680 @default.
- W1505278832 hasConcept C202751555 @default.
- W1505278832 hasConcept C2777108182 @default.
- W1505278832 hasConcept C2777551382 @default.
- W1505278832 hasConcept C2778004101 @default.
- W1505278832 hasConcept C2779924751 @default.
- W1505278832 hasConcept C2780381497 @default.
- W1505278832 hasConcept C29537977 @default.
- W1505278832 hasConcept C552990157 @default.
- W1505278832 hasConcept C55493867 @default.
- W1505278832 hasConcept C62112901 @default.
- W1505278832 hasConcept C62478195 @default.
- W1505278832 hasConcept C64241487 @default.
- W1505278832 hasConcept C86803240 @default.
- W1505278832 hasConcept C95444343 @default.
- W1505278832 hasConceptScore W1505278832C1491633281 @default.
- W1505278832 hasConceptScore W1505278832C153911025 @default.
- W1505278832 hasConceptScore W1505278832C185592680 @default.
- W1505278832 hasConceptScore W1505278832C202751555 @default.
- W1505278832 hasConceptScore W1505278832C2777108182 @default.
- W1505278832 hasConceptScore W1505278832C2777551382 @default.
- W1505278832 hasConceptScore W1505278832C2778004101 @default.
- W1505278832 hasConceptScore W1505278832C2779924751 @default.
- W1505278832 hasConceptScore W1505278832C2780381497 @default.
- W1505278832 hasConceptScore W1505278832C29537977 @default.
- W1505278832 hasConceptScore W1505278832C552990157 @default.
- W1505278832 hasConceptScore W1505278832C55493867 @default.
- W1505278832 hasConceptScore W1505278832C62112901 @default.
- W1505278832 hasConceptScore W1505278832C62478195 @default.
- W1505278832 hasConceptScore W1505278832C64241487 @default.
- W1505278832 hasConceptScore W1505278832C86803240 @default.
- W1505278832 hasConceptScore W1505278832C95444343 @default.
- W1505278832 hasIssue "3" @default.
- W1505278832 hasLocation W15052788321 @default.
- W1505278832 hasOpenAccess W1505278832 @default.
- W1505278832 hasPrimaryLocation W15052788321 @default.
- W1505278832 hasRelatedWork W1969102027 @default.
- W1505278832 hasRelatedWork W2034300049 @default.
- W1505278832 hasRelatedWork W2060442332 @default.
- W1505278832 hasRelatedWork W2066695560 @default.
- W1505278832 hasRelatedWork W2067421708 @default.
- W1505278832 hasRelatedWork W2067758824 @default.
- W1505278832 hasRelatedWork W2072481810 @default.
- W1505278832 hasRelatedWork W2084648906 @default.
- W1505278832 hasRelatedWork W2308597410 @default.
- W1505278832 hasRelatedWork W3183075330 @default.
- W1505278832 hasVolume "29" @default.
- W1505278832 isParatext "false" @default.
- W1505278832 isRetracted "false" @default.
- W1505278832 magId "1505278832" @default.
- W1505278832 workType "article" @default.