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- W1505369041 abstract "textabstractW hite matter lesions are frequently found on cerebral magnetic resonanceimaging scans of elderly non-demented and demented people.l-4 The pathogenesis of white matter lesions is largely unknown. Howeverage and high diastolic and systolic blood pressure levels and indicatorsof atherosclerosis have consistently been reported as risk factors forwhite matter lesions, regardless of their location.2-s Many other, especiallyvascular, risk factors have been associated with white matter lesions, butthese relations were mostly not consistent throughout studies.There is growing evidence that white matter lesions play an importantrole in the development of cognitive decline and dementia.4 .6 -8 Thewhite matter can be distinguished into two separate anatomical regions,namely the peri ventricular white matter (a strip of white matter adjacentto the lateral ventricles) and the subcortical white matter (the white mattcrjust underneath the gray matter). Only a few studies have distinguishedbetween these two locations and have reported on their determinantsseparately.9,10 Yet it may be that different risk factors underlie whitematter lesions at different locations, or that lesions in different locationsmay have different cognitive consequences." @default.
- W1505369041 created "2016-06-24" @default.
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- W1505369041 date "1999-03-10" @default.
- W1505369041 modified "2023-09-23" @default.
- W1505369041 title "Determinants of cerebral white matter lesions: A longitudinal population based MRI study" @default.
- W1505369041 hasPublicationYear "1999" @default.
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