Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505432219> ?p ?o ?g. }
- W1505432219 abstract "Abstract : The tumor suppressor p53 is a major player in cell growth, genomic stability and cell death. Recent in vivo work suggested that bacterial Pseudomonas aeruginosa azurin can enter cancer cells and interact with p53 promoting cell death. Despite being a novel concept to target cancer, there are no thermodynamic details known for the proposed azurin-p53 complex. This project aims to fill this gap by employing biophysical methods in conjunction with purified proteins in vitro to address four aims. We will reveal (1) which p53 domain interacts with azurin, (2) the molecular mechanism by which azurin increases cellular levels of p53, (3) the region on azurin that interacts with p53 and (4) use the acquired information to propose smaller molecules that retain properties of azurin. We have found that azurin binds to the unstructured N-terminal domain of p53 and a small peptide is able to reproduce part of the azurin interaction. We have also assessed how Cu is metabolized inside cells as well has how the crowdedness of the cell milieu affects proteins. We have made several key discoveries that will aid in the development of azurin-based molecules that can be used as new treatments of cancer." @default.
- W1505432219 created "2016-06-24" @default.
- W1505432219 creator A5014446807 @default.
- W1505432219 date "2007-09-01" @default.
- W1505432219 modified "2023-09-24" @default.
- W1505432219 title "Novel Breast Cancer Therapeutics Based on Bacterial Cupredoxin" @default.
- W1505432219 cites W1489286950 @default.
- W1505432219 cites W1563937154 @default.
- W1505432219 cites W1585758755 @default.
- W1505432219 cites W1869259273 @default.
- W1505432219 cites W1965202020 @default.
- W1505432219 cites W1969625202 @default.
- W1505432219 cites W1970127992 @default.
- W1505432219 cites W1970865115 @default.
- W1505432219 cites W1974104912 @default.
- W1505432219 cites W1977568127 @default.
- W1505432219 cites W1982243317 @default.
- W1505432219 cites W1984865271 @default.
- W1505432219 cites W1988056859 @default.
- W1505432219 cites W1988821469 @default.
- W1505432219 cites W1989137361 @default.
- W1505432219 cites W1989149251 @default.
- W1505432219 cites W1990181521 @default.
- W1505432219 cites W1993466303 @default.
- W1505432219 cites W1995838356 @default.
- W1505432219 cites W1996735555 @default.
- W1505432219 cites W2000980755 @default.
- W1505432219 cites W2003744642 @default.
- W1505432219 cites W2004175706 @default.
- W1505432219 cites W2005535197 @default.
- W1505432219 cites W2006512709 @default.
- W1505432219 cites W2008054715 @default.
- W1505432219 cites W2018204002 @default.
- W1505432219 cites W2022682828 @default.
- W1505432219 cites W2022735447 @default.
- W1505432219 cites W2024554086 @default.
- W1505432219 cites W2025442101 @default.
- W1505432219 cites W2027191063 @default.
- W1505432219 cites W2027426714 @default.
- W1505432219 cites W2029750840 @default.
- W1505432219 cites W2034284309 @default.
- W1505432219 cites W2034634716 @default.
- W1505432219 cites W2037109359 @default.
- W1505432219 cites W2041804296 @default.
- W1505432219 cites W2046089177 @default.
- W1505432219 cites W2047390883 @default.
- W1505432219 cites W2047973301 @default.
- W1505432219 cites W2051282579 @default.
- W1505432219 cites W2058075336 @default.
- W1505432219 cites W2058125899 @default.
- W1505432219 cites W2060512844 @default.
- W1505432219 cites W2063425276 @default.
- W1505432219 cites W2063452697 @default.
- W1505432219 cites W2065528345 @default.
- W1505432219 cites W2067116546 @default.
- W1505432219 cites W2068656291 @default.
- W1505432219 cites W2078862798 @default.
- W1505432219 cites W2078933151 @default.
- W1505432219 cites W2085519055 @default.
- W1505432219 cites W2085609136 @default.
- W1505432219 cites W2089625041 @default.
- W1505432219 cites W2092914966 @default.
- W1505432219 cites W2103378158 @default.
- W1505432219 cites W2111817477 @default.
- W1505432219 cites W2112733461 @default.
- W1505432219 cites W2114306033 @default.
- W1505432219 cites W2114838691 @default.
- W1505432219 cites W2131187223 @default.
- W1505432219 cites W2136617021 @default.
- W1505432219 cites W2138646489 @default.
- W1505432219 cites W2143843694 @default.
- W1505432219 cites W2148777915 @default.
- W1505432219 cites W2150705673 @default.
- W1505432219 cites W2154553490 @default.
- W1505432219 cites W2157143879 @default.
- W1505432219 cites W2160443375 @default.
- W1505432219 cites W2161781971 @default.
- W1505432219 cites W2165360511 @default.
- W1505432219 cites W2165847215 @default.
- W1505432219 cites W2170630090 @default.
- W1505432219 cites W2171941574 @default.
- W1505432219 cites W3086983054 @default.
- W1505432219 doi "https://doi.org/10.21236/ada484149" @default.
- W1505432219 hasPublicationYear "2007" @default.
- W1505432219 type Work @default.
- W1505432219 sameAs 1505432219 @default.
- W1505432219 citedByCount "0" @default.
- W1505432219 crossrefType "report" @default.
- W1505432219 hasAuthorship W1505432219A5014446807 @default.
- W1505432219 hasConcept C121608353 @default.
- W1505432219 hasConcept C12554922 @default.
- W1505432219 hasConcept C178790620 @default.
- W1505432219 hasConcept C185592680 @default.
- W1505432219 hasConcept C2778574204 @default.
- W1505432219 hasConcept C54355233 @default.
- W1505432219 hasConcept C544778455 @default.
- W1505432219 hasConcept C70721500 @default.
- W1505432219 hasConcept C86803240 @default.
- W1505432219 hasConcept C95444343 @default.
- W1505432219 hasConcept C96232424 @default.