Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505433215> ?p ?o ?g. }
- W1505433215 endingPage "1145" @default.
- W1505433215 startingPage "1123" @default.
- W1505433215 abstract "Timely reperfusion is the only way to salvage ischemic myocardium from impending infarction. However, reperfusion also adds a further component to myocardial injury such that the ultimate infarct size is the result of both ischemia- and reperfusion-induced injury. Modification of reperfusion can attenuate reperfusion injury and thus reduce infarct size. Ischemic postconditioning is a maneuver of repeated brief interruption of reperfusion by short-lasting coronary occlusions which results in reduced infarct size. Cardioprotection by ischemic postconditioning is mediated through delayed reversal of acidosis and the activation of a complex signal transduction cascade, including triggers such as adenosine, bradykinin, and opioids, mediators such as protein kinases and, notably, mitochondrial function as effector. Inhibition of the mitochondrial permeability transition pore appears to be a final signaling step of ischemic postconditioning. Several drugs which recruit in part such signaling steps of ischemic postconditioning can induce cardioprotection, even when the drug is only administered at reperfusion, that is, there is also pharmacological postconditioning. Ischemic and pharmacological postconditioning have been translated to patients with acute myocardial infarction in proof-of-concept studies, but further mechanistic insight is needed to optimize the conditions and algorithms of cardioprotection by postconditioning." @default.
- W1505433215 created "2016-06-24" @default.
- W1505433215 creator A5076082024 @default.
- W1505433215 date "2015-06-24" @default.
- W1505433215 modified "2023-10-02" @default.
- W1505433215 title "Treatment of Myocardial Ischemia/Reperfusion Injury by Ischemic and Pharmacological Postconditioning" @default.
- W1505433215 cites W1493556752 @default.
- W1505433215 cites W1528865994 @default.
- W1505433215 cites W1822689119 @default.
- W1505433215 cites W1894853873 @default.
- W1505433215 cites W1968689666 @default.
- W1505433215 cites W1968711975 @default.
- W1505433215 cites W1969912131 @default.
- W1505433215 cites W1970228194 @default.
- W1505433215 cites W1976792130 @default.
- W1505433215 cites W1980022623 @default.
- W1505433215 cites W1982815375 @default.
- W1505433215 cites W1982914035 @default.
- W1505433215 cites W1983517003 @default.
- W1505433215 cites W1984710669 @default.
- W1505433215 cites W1985129729 @default.
- W1505433215 cites W1986747691 @default.
- W1505433215 cites W1989552347 @default.
- W1505433215 cites W1991117742 @default.
- W1505433215 cites W1992672987 @default.
- W1505433215 cites W1995749170 @default.
- W1505433215 cites W1997093442 @default.
- W1505433215 cites W2004462169 @default.
- W1505433215 cites W2007939778 @default.
- W1505433215 cites W2007969381 @default.
- W1505433215 cites W2008235034 @default.
- W1505433215 cites W2008308154 @default.
- W1505433215 cites W2009574988 @default.
- W1505433215 cites W2010288573 @default.
- W1505433215 cites W2010516222 @default.
- W1505433215 cites W2012221083 @default.
- W1505433215 cites W2012517632 @default.
- W1505433215 cites W2014144028 @default.
- W1505433215 cites W2014601433 @default.
- W1505433215 cites W2015456908 @default.
- W1505433215 cites W2015499329 @default.
- W1505433215 cites W2020025868 @default.
- W1505433215 cites W2021111465 @default.
- W1505433215 cites W2021253052 @default.
- W1505433215 cites W2023570654 @default.
- W1505433215 cites W2025155186 @default.
- W1505433215 cites W2026259043 @default.
- W1505433215 cites W2026313838 @default.
- W1505433215 cites W2026878939 @default.
- W1505433215 cites W2034343042 @default.
- W1505433215 cites W2037445261 @default.
- W1505433215 cites W2037787788 @default.
- W1505433215 cites W2040174386 @default.
- W1505433215 cites W2042476232 @default.
- W1505433215 cites W2042503285 @default.
- W1505433215 cites W2042690788 @default.
- W1505433215 cites W2043355876 @default.
- W1505433215 cites W2044467032 @default.
- W1505433215 cites W2047563687 @default.
- W1505433215 cites W2048005596 @default.
- W1505433215 cites W2049043910 @default.
- W1505433215 cites W2050192427 @default.
- W1505433215 cites W2052311383 @default.
- W1505433215 cites W2054813195 @default.
- W1505433215 cites W2054903524 @default.
- W1505433215 cites W2055642563 @default.
- W1505433215 cites W2058441947 @default.
- W1505433215 cites W2058795101 @default.
- W1505433215 cites W2059877258 @default.
- W1505433215 cites W2061153812 @default.
- W1505433215 cites W2062777516 @default.
- W1505433215 cites W2063873454 @default.
- W1505433215 cites W2064147834 @default.
- W1505433215 cites W2065218555 @default.
- W1505433215 cites W2066931754 @default.
- W1505433215 cites W2068007378 @default.
- W1505433215 cites W2070364693 @default.
- W1505433215 cites W2071831285 @default.
- W1505433215 cites W2072191752 @default.
- W1505433215 cites W2075248415 @default.
- W1505433215 cites W2075635893 @default.
- W1505433215 cites W2079804018 @default.
- W1505433215 cites W2079871208 @default.
- W1505433215 cites W2080276645 @default.
- W1505433215 cites W2080411283 @default.
- W1505433215 cites W2081787098 @default.
- W1505433215 cites W2082329828 @default.
- W1505433215 cites W2085591677 @default.
- W1505433215 cites W2087126389 @default.
- W1505433215 cites W2087805943 @default.
- W1505433215 cites W2088448333 @default.
- W1505433215 cites W2089178918 @default.
- W1505433215 cites W2090842782 @default.
- W1505433215 cites W2091020908 @default.
- W1505433215 cites W2092914889 @default.
- W1505433215 cites W2093494462 @default.
- W1505433215 cites W2096541614 @default.
- W1505433215 cites W2098329072 @default.