FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505454328> ?p ?o ?g. }

• W1505454328 endingPage "152" @default.
• W1505454328 startingPage "149" @default.
• W1505454328 abstract "Gamma Knife surgery (GKS) is gaining popularity in the treatment of patients with acromegaly after transsphenoidal tumor excision. In this paper, the authors examine the efficacy of GKS and predictors for biochemical remission.The authors retrospectively reviewed data spanning the period 1997–2008 in their hospital Gamma Knife statistics database. Forty patients with a mean age of 64 years (range 19–73 years) underwent GKS for acromegaly during that period. Transsphenoidal subtotal tumor excision had been performed prior to GKS in all these patients, except for 3 deemed to be at high surgical risk. All GKS treatment plans were formulated by the same team that performed the microsurgical procedures. Biochemical remission was defined as a growth hormone (GH) level <2 ng/ml and an insulin-like growth factor–I level that was considered normal with reference to the patient's age and sex. The mean follow-up period after radiosurgery was 73.8 months (range 12–132 months).Three patients died during the study period of causes unrelated to surgery or GKS. Twenty-nine patients (72.5%) underwent 1 radiosurgery session, and 11 patients (27.5%) required 2 radiosurgery sessions. Among the patients who underwent 1 radiosurgery session, excellent responses (76%–100% reductions in tumor size, GH level, and insulin-like growth factor–I level) were observed in 18 (62%; p < 0.0001), 20 (69%; p < 0.0001), and 5 patients (17%; p = 0.21), respectively. Tumors < 1 cm³ and those with no evidence of cavernous sinus extension were statistically significantly related to a good response in tumor size reduction (p = 0.029 and p = 0.0016, respectively). Subgroup analyses were performed in patients who attained biochemical remission in GH levels; the subgroups included patient sex, patient age, target volume, isodose volume, prescribed dose and isodose, pre-GKS GH level, and evidence of cavernous sinus extension. Only male sex was found to be a statistically significant predictor of good hormone regulation (p = 0.0124). The presence of a cavernous sinus extension was the statistically significant predictor of poor hormone control (p = 0.0011) in our study.Subtotal tumor excision followed by GKS was an effective treatment for acromegaly. Tumors < 1 cm³ and those with no evidence of cavernous sinus extension responded well to treatment. Male sex and absence of cavernous sinus involvement can be regarded as predictors of biochemical remission. (DOI: 10.3171/2010.7.GKS10" @default.
• W1505454328 created "2016-06-24" @default.
• W1505454328 creator A5004879372 @default.
• W1505454328 creator A5025949059 @default.
• W1505454328 creator A5053261210 @default.
• W1505454328 creator A5057463661 @default.
• W1505454328 date "2010-12-01" @default.
• W1505454328 modified "2023-09-26" @default.
• W1505454328 title "Predictors of outcome following Gamma Knife surgery for acromegaly." @default.
• W1505454328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21222293" @default.
• W1505454328 hasPublicationYear "2010" @default.
• W1505454328 type Work @default.
• W1505454328 sameAs 1505454328 @default.
• W1505454328 citedByCount "9" @default.
• W1505454328 countsByYear W15054543282012 @default.
• W1505454328 countsByYear W15054543282013 @default.
• W1505454328 countsByYear W15054543282015 @default.
• W1505454328 countsByYear W15054543282016 @default.
• W1505454328 countsByYear W15054543282017 @default.
• W1505454328 countsByYear W15054543282018 @default.
• W1505454328 countsByYear W15054543282020 @default.
• W1505454328 crossrefType "journal-article" @default.
• W1505454328 hasAuthorship W1505454328A5004879372 @default.
• W1505454328 hasAuthorship W1505454328A5025949059 @default.
• W1505454328 hasAuthorship W1505454328A5053261210 @default.
• W1505454328 hasAuthorship W1505454328A5057463661 @default.
• W1505454328 hasConcept C126322002 @default.
• W1505454328 hasConcept C141071460 @default.
• W1505454328 hasConcept C2777428134 @default.
• W1505454328 hasConcept C2777433750 @default.
• W1505454328 hasConcept C2779318953 @default.
• W1505454328 hasConcept C2779653919 @default.
• W1505454328 hasConcept C2780387249 @default.
• W1505454328 hasConcept C2984496839 @default.
• W1505454328 hasConcept C2994042627 @default.
• W1505454328 hasConcept C509974204 @default.
• W1505454328 hasConcept C71315377 @default.
• W1505454328 hasConcept C71924100 @default.
• W1505454328 hasConceptScore W1505454328C126322002 @default.
• W1505454328 hasConceptScore W1505454328C141071460 @default.
• W1505454328 hasConceptScore W1505454328C2777428134 @default.
• W1505454328 hasConceptScore W1505454328C2777433750 @default.
• W1505454328 hasConceptScore W1505454328C2779318953 @default.
• W1505454328 hasConceptScore W1505454328C2779653919 @default.
• W1505454328 hasConceptScore W1505454328C2780387249 @default.
• W1505454328 hasConceptScore W1505454328C2984496839 @default.
• W1505454328 hasConceptScore W1505454328C2994042627 @default.
• W1505454328 hasConceptScore W1505454328C509974204 @default.
• W1505454328 hasConceptScore W1505454328C71315377 @default.
• W1505454328 hasConceptScore W1505454328C71924100 @default.
• W1505454328 hasLocation W15054543281 @default.
• W1505454328 hasOpenAccess W1505454328 @default.
• W1505454328 hasPrimaryLocation W15054543281 @default.
• W1505454328 hasRelatedWork W1946116870 @default.
• W1505454328 hasRelatedWork W1975943105 @default.
• W1505454328 hasRelatedWork W1990927040 @default.
• W1505454328 hasRelatedWork W2007956690 @default.
• W1505454328 hasRelatedWork W2025188641 @default.
• W1505454328 hasRelatedWork W2027794460 @default.
• W1505454328 hasRelatedWork W2029304376 @default.
• W1505454328 hasRelatedWork W2045311197 @default.
• W1505454328 hasRelatedWork W2066646119 @default.
• W1505454328 hasRelatedWork W2066892167 @default.
• W1505454328 hasRelatedWork W2076801920 @default.
• W1505454328 hasRelatedWork W2088653136 @default.
• W1505454328 hasRelatedWork W2093504923 @default.
• W1505454328 hasRelatedWork W2136335235 @default.
• W1505454328 hasRelatedWork W2145953975 @default.
• W1505454328 hasRelatedWork W2147854474 @default.
• W1505454328 hasRelatedWork W2150771753 @default.
• W1505454328 hasRelatedWork W2166007818 @default.
• W1505454328 hasRelatedWork W3033164618 @default.
• W1505454328 hasRelatedWork W1556999253 @default.
• W1505454328 hasVolume "113 Suppl" @default.
• W1505454328 isParatext "false" @default.
• W1505454328 isRetracted "false" @default.
• W1505454328 magId "1505454328" @default.
• W1505454328 workType "article" @default.