Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505462695> ?p ?o ?g. }
- W1505462695 endingPage "656" @default.
- W1505462695 startingPage "647" @default.
- W1505462695 abstract "John M. Eagles suggested that polioviruses might cause schizophrenia because 1) several reports of a recent decline in the incidence of schizophrenia coinciding with the introduction of polio vaccination, 2) the observed winter excesses in schizophrenic births (in temperate climates) could be explained by fetal exposure to poliovirus during the second trimester of gestation which would occur during the summer when polio epidemics are most frequent, 3) there are increased rates of schizophrenia among immigrants to the UK from regions of the world with low frequencies if immunity to polioviruses, 4) there may be genetic variants in the poliovirus receptor gene that could increase susceptibility to poliovirus infection (1). The large discordance rates for schizophrenia in monozygotic twin pairs indicate the existence of both genetic and environmental factors. Numerous genetic studies indicate an interaction of several genes in the etiology of schizophrenia. These genes may encode a family of poliovirus receptor subunits, various active combinations of which are expressed on T-immunocytes, monocytes, endothelial cells, and limited populations of (glutamatergic?) neurons. The poliovirus receptor on the T-cell may require both a specific combination of V segments of the T-cell antigen receptor, as well as a specific major histocompatibility (MHC) antigen, acting in concert to infect monocytes, the primary transporter of poliovirus from blood into the brain. The very large discordance rates for schizophrenia that probably exist for dichorionic-monozygotic twins (about 90%), as well as the much smaller discordance rates for monochorionic-monozygotic twins (about 40%), may be due to several allelic exclusion events expressed both in T-cells and possibly in certain neurons. A child who has lost some glutamatergic neurons due to viral infection during the second trimester of gestation, may be able to compensate for this deficit to a large extent by the super-abundance of excitatory synapses that exists in the brain until sexual maturity, at which time a selective loss of excitatory (mainly glutamatergic) synapses occurs together with hormonally induced changes in behavior, leading to a much increased risk of a psychotic episode." @default.
- W1505462695 created "2016-06-24" @default.
- W1505462695 creator A5067942712 @default.
- W1505462695 date "1997-01-01" @default.
- W1505462695 modified "2023-09-25" @default.
- W1505462695 cites W1776910437 @default.
- W1505462695 cites W1798984988 @default.
- W1505462695 cites W1892785680 @default.
- W1505462695 cites W1950026089 @default.
- W1505462695 cites W1964007647 @default.
- W1505462695 cites W1965871695 @default.
- W1505462695 cites W1968629708 @default.
- W1505462695 cites W1972868253 @default.
- W1505462695 cites W1975317154 @default.
- W1505462695 cites W1978380013 @default.
- W1505462695 cites W1978978846 @default.
- W1505462695 cites W1979987243 @default.
- W1505462695 cites W1981440980 @default.
- W1505462695 cites W1981644527 @default.
- W1505462695 cites W1983967908 @default.
- W1505462695 cites W1988642048 @default.
- W1505462695 cites W1990840023 @default.
- W1505462695 cites W1990941333 @default.
- W1505462695 cites W1995362640 @default.
- W1505462695 cites W1997211407 @default.
- W1505462695 cites W2005419614 @default.
- W1505462695 cites W2006998557 @default.
- W1505462695 cites W2008158398 @default.
- W1505462695 cites W2008204361 @default.
- W1505462695 cites W2008621323 @default.
- W1505462695 cites W2008825237 @default.
- W1505462695 cites W2010494816 @default.
- W1505462695 cites W2012113068 @default.
- W1505462695 cites W2016150080 @default.
- W1505462695 cites W2017094771 @default.
- W1505462695 cites W2017105911 @default.
- W1505462695 cites W2023095125 @default.
- W1505462695 cites W2023469110 @default.
- W1505462695 cites W2024664667 @default.
- W1505462695 cites W2025011978 @default.
- W1505462695 cites W2030330127 @default.
- W1505462695 cites W2035723743 @default.
- W1505462695 cites W2036690206 @default.
- W1505462695 cites W2037379301 @default.
- W1505462695 cites W2037768954 @default.
- W1505462695 cites W2038092706 @default.
- W1505462695 cites W2041713925 @default.
- W1505462695 cites W2050028034 @default.
- W1505462695 cites W2050637828 @default.
- W1505462695 cites W2050711988 @default.
- W1505462695 cites W2052627099 @default.
- W1505462695 cites W2053373257 @default.
- W1505462695 cites W2059864318 @default.
- W1505462695 cites W2060361076 @default.
- W1505462695 cites W2062903022 @default.
- W1505462695 cites W2065528892 @default.
- W1505462695 cites W2066934298 @default.
- W1505462695 cites W2067709496 @default.
- W1505462695 cites W2068012172 @default.
- W1505462695 cites W2070686690 @default.
- W1505462695 cites W2072830463 @default.
- W1505462695 cites W2073999820 @default.
- W1505462695 cites W2075067177 @default.
- W1505462695 cites W2076924133 @default.
- W1505462695 cites W2077223767 @default.
- W1505462695 cites W2077384761 @default.
- W1505462695 cites W2084793063 @default.
- W1505462695 cites W2085571100 @default.
- W1505462695 cites W2087103552 @default.
- W1505462695 cites W2107233221 @default.
- W1505462695 cites W2109999754 @default.
- W1505462695 cites W2111017842 @default.
- W1505462695 cites W2113359311 @default.
- W1505462695 cites W2113908711 @default.
- W1505462695 cites W2130620798 @default.
- W1505462695 cites W2154015462 @default.
- W1505462695 cites W2154122353 @default.
- W1505462695 cites W2158302852 @default.
- W1505462695 cites W2163863628 @default.
- W1505462695 cites W2164234728 @default.
- W1505462695 cites W2164781516 @default.
- W1505462695 cites W2165516651 @default.
- W1505462695 cites W2166567095 @default.
- W1505462695 cites W2170836478 @default.
- W1505462695 cites W2313877543 @default.
- W1505462695 cites W2412371605 @default.
- W1505462695 cites W2419069175 @default.
- W1505462695 cites W2566222762 @default.
- W1505462695 cites W27388469 @default.
- W1505462695 cites W3144225933 @default.
- W1505462695 cites W37715129 @default.
- W1505462695 cites W99077541 @default.
- W1505462695 cites W2137631028 @default.
- W1505462695 cites W2417696367 @default.
- W1505462695 doi "https://doi.org/10.1023/a:1022486423238" @default.
- W1505462695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9131645" @default.
- W1505462695 hasPublicationYear "1997" @default.
- W1505462695 type Work @default.