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• W1505473896 abstract "Abstract Members of the TGF‐β super‐family regulate differentiation, proliferation, growth arrest, and apoptosis. TGF‐β mediated signalling proceeds via binding of the ligand to membrane receptor kinases, phosphorylation of TβRII receptor to the TβRI receptor kinase, and subsequently Smad activation, resulting in gene transcription. Dysfunctional TGF‐β signalling is associated with cancer development and progression, while TGF‐β ligand secretion and activation enhances tumour aggressiveness and correlates with metastatic behaviour in human tumours. Molecular exploitation of defective signalling effectors of this pathway is of major significance in detection and therapeutic targeting of human cancers. The present chapter summarizes the current knowledge on the contribution of dysfunctional TGF‐β1 signalling in tumour development and progression and its relevance in cancer prognosis and therapy." @default.
• W1505473896 created "2016-06-24" @default.
• W1505473896 creator A5001059831 @default.
• W1505473896 creator A5028617589 @default.
• W1505473896 date "2007-10-15" @default.
• W1505473896 modified "2023-10-10" @default.
• W1505473896 title "Transforming Growth Factor‐β and Cancer" @default.
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