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- W1505655130 abstract "HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV‐induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly caused by perforin‐expressing cytotoxic T cells. In chronic infection, mucosal production of inflammatory cytokines is associated with increased epithelial permeability, epithelial apoptosis, and alterations of epithelial tight junctions. In addition to HIV‐induced immune‐mediated effects, viral proteins have the potential to directly affect epithelial barrier function. After prolonged viral suppression by antiretroviral therapy, there is, at least partial, restoration of the HIV‐associated intestinal mucosal barrier defect despite persisting alterations of the mucosal immune system." @default.
- W1505655130 created "2016-06-24" @default.
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- W1505655130 date "2012-06-25" @default.
- W1505655130 modified "2023-10-04" @default.
- W1505655130 title "HIV infection and the intestinal mucosal barrier" @default.
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- W1505655130 doi "https://doi.org/10.1111/j.1749-6632.2012.06512.x" @default.
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