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- W1505661903 abstract "Idiotype conservation between human and mouse antibodies has been observed in association with various infectious and autoimmune diseases. We have isolated a human anti-idiotypic antibody to a mouse monoclonal anti-IgE antibody (BSW17) suggesting a conserved interspecies idiotype associated with an anti-IgE response. To find the homologue of BSW17 in the human genome we applied the guided selection strategy. Combining VH of BSW17 with a human VL repertoire resulted in three light chains. The three VL chains were then combined with a human VH repertoire resulting in three clones specific for human IgE. Surprisingly, one clone, Hu41, had the same epitope specificity and functional in vitro activity as BSW17 and VH complementarity-determining regions identical with that of BSW17. Real-time PCR analysis confirmed the presence of the Hu41 VH sequence in the human genome. These data document the first example of the isolation of a human antibody where high sequence similarity to the original murine VH sequence is associated with common antigen and epitope specificity." @default.
- W1505661903 created "2016-06-24" @default.
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- W1505661903 date "2004-08-01" @default.
- W1505661903 modified "2023-10-18" @default.
- W1505661903 title "A Highly Conserved Interspecies V H in the Human Genome" @default.
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- W1505661903 doi "https://doi.org/10.1016/j.jmb.2004.06.011" @default.
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