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- W1505679995 abstract "Platelets might be involved in the pathogenesis of diabetic microangiopathy. Wide interindividual variations in the density of a platelet collagen receptor (2β1 integrin or glycoprotein Ia/IIa) are reportedly associated with polymorphism(s) in the gene encoding the subunit of the receptor, including a Bgl II polymorphism in intron 7. The aim of the present study was to determine the relationship between the Bgl II polymorphism and the susceptibility to diabetic microangiopathy. A case-control study comparing 227 patients with type II diabetes mellitus (119 with versus 108 without diabetic retinopathy) as well as 169 nondiabetic subjects demonstrated that genotypes with Bgl II (+) allele had a significant increase in the risk for retinopathy. The odds ratio for Bgl II (+/+) to Bgl II (−/−) was 3.41 (95% CI, 1.49-7.78, P = .0036) when analysis was confined to those with a disease duration of diabetes of 10 years or more. The present study suggests that the presence of a Bg II (+) allele is a genetic risk factor for diabetic retinopathy." @default.
- W1505679995 created "2016-06-24" @default.
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- W1505679995 date "2000-03-01" @default.
- W1505679995 modified "2023-10-01" @default.
- W1505679995 title "Association between diabetic retinopathy and genetic variations in α2β1 integrin, a platelet receptor for collagen" @default.
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- W1505679995 doi "https://doi.org/10.1182/blood.v95.5.1560.005k43_1560_1564" @default.
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