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- W150570018 abstract "Gene therapy appears to be an attractive modality for accelerating wound healing, as only temporary gene expression is required to achieve a desirable therapeutic outcome. We describe a crosslinked hyaluronan (HA) biocompatible and biodegradable matrix for sustained gene transfer. Results from in vitro DNA release kinetics studies indicate that this hyaluronan-DNA bioconjugate is capable of prolonged release of DNA. Electrophoretic motility studies indicate that the DNA released from this delivery vehicle is intact. The DNA samples collected during the course of the release study were successfully used for transfecting cell cultures. DNA-HA matrix with a 0.5% DNA (encoding a β-galactosidase gene) loading was implanted into pig subdermal (endodermis) biopsy wounds. Extensive gene transfer was observed after 12 days of implantation. This gene delivery matrix system could be used for sustained delivery of plasmid DNA encoding a cytokine (e.g., Platelet Derived Growth Factor) as a single application therapeutic for accelerating chronic wound healing." @default.
- W150570018 created "2016-06-24" @default.
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- W150570018 date "2002-01-01" @default.
- W150570018 modified "2023-09-25" @default.
- W150570018 title "HYALURONAN DNA MATRIX FOR GENE TRANSFER" @default.
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- W150570018 doi "https://doi.org/10.1533/9781845693121.305" @default.
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