FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505732908> ?p ?o ?g. }

• W1505732908 abstract "Abstract : In this study we have examined the interaction between the guanine nucleotide exchange factor, Tiam1, and the cytoskeletal protein, ankyrin, in metastatic breast cancer cells (Met-1 cell line). Immunoblot assay using anti-Tiam1-specific antibody shows that Tiam1 is a 200 kDa polypeptide in Met-1 cells. Structural analysis indicates that the amino acid sequence, (717)GEGTDAVKRS(727)L, in Tiam1 shares a great deal of structural homology with the ankyrin-binding domain located in CD44 isoforms. Most importantly, we have determined that ankyrin binding to Tiam1 activates GDP-GTP exchange on RhoA. In addition, overexpression of Tiam1 (by transfecting Met-1 cell with Tiam1 cDNAs) induces ankyrin-linked cytoskeletal changes and membrane motility (e.g., membrane spikes and ruffling), tumor cell invasion and migration. Finally, we have constructed a Tiam1 deletion mutant lacking the ankyrin binding site. This truncated cDNA was then transiently transfected into Met-1 cells. Our results indicate that this Tiam1 deletion mutant (lacking an ankyrin binding and displaying a reduced GDP-GTP exchange activity for RhoA) functions as a potent dominant-negative form of Tiam1 which effectively inhibits metastatic tumor cell behaviors. These findings strongly suggest that the ankyrin binding site located within Tiam1 plays a pivotal role in RhoA activation required for ankyrin-based cytoskeleton function and oncogenic signaling (e.g., membrane motility, tumor cell invasion and migration) during metastatic breast tumor cell progression." @default.
• W1505732908 created "2016-06-24" @default.
• W1505732908 creator A5069496915 @default.
• W1505732908 date "1999-08-01" @default.
• W1505732908 modified "2023-09-26" @default.
• W1505732908 title "A New Invasion and Metastasis Molecule, TIAMI1, and Its Interaction with the Cytoskeleton are Involved in Human Breast Cancer Progression" @default.
• W1505732908 cites W106628407 @default.
• W1505732908 cites W1484050792 @default.
• W1505732908 cites W1505736789 @default.
• W1505732908 cites W1507054304 @default.
• W1505732908 cites W1523499855 @default.
• W1505732908 cites W1526649778 @default.
• W1505732908 cites W1553199687 @default.
• W1505732908 cites W1555753650 @default.
• W1505732908 cites W1568020570 @default.
• W1505732908 cites W1583486328 @default.
• W1505732908 cites W1593480505 @default.
• W1505732908 cites W1599429565 @default.
• W1505732908 cites W1606121092 @default.
• W1505732908 cites W1797333478 @default.
• W1505732908 cites W1905169438 @default.
• W1505732908 cites W1910507932 @default.
• W1505732908 cites W1913164203 @default.
• W1505732908 cites W1929801845 @default.
• W1505732908 cites W1966706677 @default.
• W1505732908 cites W1967265143 @default.
• W1505732908 cites W1978265453 @default.
• W1505732908 cites W1983237422 @default.
• W1505732908 cites W1985709351 @default.
• W1505732908 cites W1989143807 @default.
• W1505732908 cites W1992589123 @default.
• W1505732908 cites W1993072748 @default.
• W1505732908 cites W1994139415 @default.
• W1505732908 cites W1995843335 @default.
• W1505732908 cites W2007660746 @default.
• W1505732908 cites W2009575166 @default.
• W1505732908 cites W2010599629 @default.
• W1505732908 cites W2011756230 @default.
• W1505732908 cites W2021289405 @default.
• W1505732908 cites W2027810531 @default.
• W1505732908 cites W2032384795 @default.
• W1505732908 cites W2034566357 @default.
• W1505732908 cites W2037670359 @default.
• W1505732908 cites W2044415802 @default.
• W1505732908 cites W2045094350 @default.
• W1505732908 cites W2070082950 @default.
• W1505732908 cites W2077003488 @default.
• W1505732908 cites W2077792958 @default.
• W1505732908 cites W2088028188 @default.
• W1505732908 cites W2091484152 @default.
• W1505732908 cites W2099731590 @default.
• W1505732908 cites W2112327424 @default.
• W1505732908 cites W2112668385 @default.
• W1505732908 cites W2127529738 @default.
• W1505732908 cites W2127984477 @default.
• W1505732908 cites W2135264351 @default.
• W1505732908 cites W2135923382 @default.
• W1505732908 cites W2140481166 @default.
• W1505732908 cites W2159657475 @default.
• W1505732908 cites W49986325 @default.
• W1505732908 doi "https://doi.org/10.21236/ada376471" @default.
• W1505732908 hasPublicationYear "1999" @default.
• W1505732908 type Work @default.
• W1505732908 sameAs 1505732908 @default.
• W1505732908 citedByCount "0" @default.
• W1505732908 crossrefType "report" @default.
• W1505732908 hasAuthorship W1505732908A5069496915 @default.
• W1505732908 hasConcept C121608353 @default.
• W1505732908 hasConcept C126322002 @default.
• W1505732908 hasConcept C142669718 @default.
• W1505732908 hasConcept C1491633281 @default.
• W1505732908 hasConcept C2779013556 @default.
• W1505732908 hasConcept C2992691968 @default.
• W1505732908 hasConcept C2993589390 @default.
• W1505732908 hasConcept C2994423619 @default.
• W1505732908 hasConcept C502942594 @default.
• W1505732908 hasConcept C530470458 @default.
• W1505732908 hasConcept C54355233 @default.
• W1505732908 hasConcept C71924100 @default.
• W1505732908 hasConcept C86803240 @default.
• W1505732908 hasConceptScore W1505732908C121608353 @default.
• W1505732908 hasConceptScore W1505732908C126322002 @default.
• W1505732908 hasConceptScore W1505732908C142669718 @default.
• W1505732908 hasConceptScore W1505732908C1491633281 @default.
• W1505732908 hasConceptScore W1505732908C2779013556 @default.
• W1505732908 hasConceptScore W1505732908C2992691968 @default.
• W1505732908 hasConceptScore W1505732908C2993589390 @default.
• W1505732908 hasConceptScore W1505732908C2994423619 @default.
• W1505732908 hasConceptScore W1505732908C502942594 @default.
• W1505732908 hasConceptScore W1505732908C530470458 @default.
• W1505732908 hasConceptScore W1505732908C54355233 @default.
• W1505732908 hasConceptScore W1505732908C71924100 @default.
• W1505732908 hasConceptScore W1505732908C86803240 @default.
• W1505732908 hasLocation W15057329081 @default.
• W1505732908 hasOpenAccess W1505732908 @default.
• W1505732908 hasPrimaryLocation W15057329081 @default.
• W1505732908 hasRelatedWork W2055209420 @default.
• W1505732908 hasRelatedWork W2121789222 @default.
• W1505732908 hasRelatedWork W2134945055 @default.
• W1505732908 hasRelatedWork W2391661635 @default.

• next