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• W1505735082 abstract "Bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor-A (VEGF-A), was originally developed as an anti-tumor treatment. In ocular oncology, it is being used to treat macular edema due to radiation retinopathy, but it may also be useful for the treatment of primary uveal melanoma (UM) or its metastases. We determined the effect of bevacizumab on the growth of B16F10 cells inside the eye and on B16F10 and UM cells cultured in vitro.B16F10 melanoma cells were placed into the anterior chamber of the eye of C57Bl/6 mice and tumor growth was monitored after injection of different doses of bevacizumab or mock injection. In addition, the effect of bevacizumab on in vitro growth of B16F10 and human UM cells and on the expression of VEGF-A, GLUT-1, and HIF-1α was evaluated.Following intraocular injection of bevacizumab into murine B16 tumor-containing eyes, an acceleration of tumor growth was observed, with the occurrence of anterior chamber hemorrhages. Bevacizumab did not affect proliferation of B16F10 cells in vitro, while it inhibited UM cell proliferation. Expression analysis demonstrated that addition of bevacizumab under hypoxic conditions induced VEGF-A, GLUT-1 and HIF-1α in B16F10 cells as well as in UM cell lines and two of four primary UM tumor cultures.In contrast with expectations, intraocular injection of bevacizumab stimulated B16F10 melanoma growth in murine eyes. In vitro exposure of B16 and human UM cells to bevacizumab led to paradoxical VEGF-A upregulation. The use of VEGF inhibitors for treatment of macular edema (due to radiation retinopathy) after irradiation of UM should be considered carefully, because of the possible adverse effects on residual UM cells." @default.
• W1505735082 created "2016-06-24" @default.
• W1505735082 creator A5006572470 @default.
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• W1505735082 date "2012-01-01" @default.
• W1505735082 modified "2023-09-23" @default.
• W1505735082 title "Bevacizumab and intraocular tumors: an intriguing paradox." @default.
• W1505735082 cites W1479731182 @default.
• W1505735082 cites W1972925452 @default.
• W1505735082 cites W1974005709 @default.
• W1505735082 cites W1976266620 @default.
• W1505735082 cites W1976811449 @default.
• W1505735082 cites W1977999028 @default.
• W1505735082 cites W1982314128 @default.
• W1505735082 cites W1983080958 @default.
• W1505735082 cites W1983847364 @default.
• W1505735082 cites W1988258153 @default.
• W1505735082 cites W1992591040 @default.
• W1505735082 cites W1995124125 @default.
• W1505735082 cites W2003015532 @default.
• W1505735082 cites W2003775520 @default.
• W1505735082 cites W2006439921 @default.
• W1505735082 cites W2012852444 @default.
• W1505735082 cites W2013145271 @default.
• W1505735082 cites W2013775811 @default.
• W1505735082 cites W2016284281 @default.
• W1505735082 cites W2019852742 @default.
• W1505735082 cites W2020021293 @default.
• W1505735082 cites W2024076257 @default.
• W1505735082 cites W2026382240 @default.
• W1505735082 cites W2030067542 @default.
• W1505735082 cites W2030636749 @default.
• W1505735082 cites W2030998830 @default.
• W1505735082 cites W2033710219 @default.
• W1505735082 cites W2035337464 @default.
• W1505735082 cites W2038294352 @default.
• W1505735082 cites W2041087650 @default.
• W1505735082 cites W2046507292 @default.
• W1505735082 cites W2049349346 @default.
• W1505735082 cites W2049650439 @default.
• W1505735082 cites W2050499474 @default.
• W1505735082 cites W2055835855 @default.
• W1505735082 cites W2058875134 @default.
• W1505735082 cites W2060104085 @default.
• W1505735082 cites W2063218096 @default.
• W1505735082 cites W2066348781 @default.
• W1505735082 cites W2067020920 @default.
• W1505735082 cites W2068014745 @default.
• W1505735082 cites W2074783201 @default.
• W1505735082 cites W2080886828 @default.
• W1505735082 cites W2085712747 @default.
• W1505735082 cites W2090093512 @default.
• W1505735082 cites W2092409918 @default.
• W1505735082 cites W2092522736 @default.
• W1505735082 cites W2095479209 @default.
• W1505735082 cites W2102483598 @default.
• W1505735082 cites W2107638902 @default.
• W1505735082 cites W2115898240 @default.
• W1505735082 cites W2118947035 @default.
• W1505735082 cites W2123123877 @default.
• W1505735082 cites W2124415048 @default.
• W1505735082 cites W2132136625 @default.
• W1505735082 cites W2138549688 @default.
• W1505735082 cites W2140088548 @default.
• W1505735082 cites W2143146123 @default.
• W1505735082 cites W2144660856 @default.
• W1505735082 cites W2147850345 @default.
• W1505735082 cites W2148794649 @default.
• W1505735082 cites W2150021876 @default.
• W1505735082 cites W2152474871 @default.
• W1505735082 cites W2156018975 @default.
• W1505735082 cites W2159841299 @default.
• W1505735082 cites W2160706109 @default.
• W1505735082 cites W2164279183 @default.
• W1505735082 cites W2164971856 @default.
• W1505735082 cites W2306203824 @default.
• W1505735082 cites W2915852396 @default.
• W1505735082 cites W33364968 @default.
• W1505735082 cites W1592374540 @default.
• W1505735082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3472924" @default.
• W1505735082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23077404" @default.
• W1505735082 hasPublicationYear "2012" @default.
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