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- W1505777364 abstract "In the mouse, germ cells can undergo differentiationto become either oocytes or spermatozoa in response to sex of theirgonadal environment. The nature of the germ cell-intrinsic aspectsof this signaling have not been well studied. The earliest knownsex-specific difference in germ cells is the initiation of meiosisin female, but not male, embryonic germ cells. Experiments wereperformed showing that germ cells of both sexes transit through astate, the meiosis competent germ cell, that is required forinitiation of meiosis. Acquisition of this state requires thefunction of the germ cellspecific RNA binding protein DAZL. Thesufficiency for the absence of meiosis to drive male germ celldifferentiation was then tested by examining non-meiotic XX germcells in the Dazl-deficient ovary. These cells did not exhibit maledifferentiation indicating that the absence of meiosis is notsufficient for male differentiation. XX Dazl-deficient germ cellsalso failed to exhibit normal female differentiation. In addition,XY Dazl-deficient germ cells do not display characteristics ofeither male or female germ cells. Taken together, these resultsindicate that germ cells must first undergo a sex non-specificdifferentiation step prior to acquiring sexualfate." @default.
- W1505777364 created "2016-06-24" @default.
- W1505777364 creator A5053409027 @default.
- W1505777364 date "2010-01-01" @default.
- W1505777364 modified "2023-09-27" @default.
- W1505777364 title "Dazl regulates mouse embryonic germ cell development" @default.
- W1505777364 hasPublicationYear "2010" @default.
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