Matches in SemOpenAlex for { <https://semopenalex.org/work/W1505785538> ?p ?o ?g. }
- W1505785538 endingPage "223" @default.
- W1505785538 startingPage "199" @default.
- W1505785538 abstract "It is now commonly accepted that neuronal plasticity plays a central role in depression and antidepressant drug action. Accumulating evidence from studies in both humans and animals suggests that depression is associated with alterations in the cellular architecture of specific brain regions that are important for the regulation of mood. Moreover, many of these changes are attenuated or reversed by chronic antidepressant treatment. Since neurotrophic factors regulate many features of neuronal plasticity including the proliferation and structure of neurons, there is a rapidly growing interest in determining whether growth factor signalling might contribute to the pathophysiology and treatment of depression. Several families of neurotrophic factors are found in the adult brain including the neurotrophins, fibroblast growth factors, insulin-like growth factors, transforming growth factors, neuropoietic cytokines as well as various other growth factors such as vascular endothelial growth factor. Of all the neurotrophic factors, brain-derived neurotrophic factor (BDNF) has been the most intensively investigated in the depression and antidepressant research field, and there is convincing supporting evidence of a role for BDNF in the pathophysiology and treatment of depression. Additional evidence suggests that other neurotrophic factors, such as fibroblast growth factor, vascular endothelial growth factor and insulin-like growth factor 1, might also contribute to the mechanism of antidepressant drug action, although more exhaustive investigations are required. The present chapter reviews both human and animal studies investigating the roles of neurotrophic factors in the pathophysiology and treatment of depression." @default.
- W1505785538 created "2016-06-24" @default.
- W1505785538 creator A5019744869 @default.
- W1505785538 creator A5041317939 @default.
- W1505785538 date "2010-01-01" @default.
- W1505785538 modified "2023-10-16" @default.
- W1505785538 title "Neurotrophic Factors and Antidepressant Action: Recent Advances" @default.
- W1505785538 cites W1530984097 @default.
- W1505785538 cites W1647455825 @default.
- W1505785538 cites W1864437270 @default.
- W1505785538 cites W1914011667 @default.
- W1505785538 cites W1965815632 @default.
- W1505785538 cites W1966048742 @default.
- W1505785538 cites W1966652032 @default.
- W1505785538 cites W1967017538 @default.
- W1505785538 cites W1967379094 @default.
- W1505785538 cites W1967421959 @default.
- W1505785538 cites W1968213313 @default.
- W1505785538 cites W1969113092 @default.
- W1505785538 cites W1969813549 @default.
- W1505785538 cites W1970174523 @default.
- W1505785538 cites W1971208141 @default.
- W1505785538 cites W1971606760 @default.
- W1505785538 cites W1972739162 @default.
- W1505785538 cites W1972759067 @default.
- W1505785538 cites W1972764203 @default.
- W1505785538 cites W1974787539 @default.
- W1505785538 cites W1976204457 @default.
- W1505785538 cites W1977237592 @default.
- W1505785538 cites W1977248973 @default.
- W1505785538 cites W1977606691 @default.
- W1505785538 cites W1977689367 @default.
- W1505785538 cites W1977823588 @default.
- W1505785538 cites W1978483423 @default.
- W1505785538 cites W1978696776 @default.
- W1505785538 cites W1978891587 @default.
- W1505785538 cites W1978925706 @default.
- W1505785538 cites W1979125819 @default.
- W1505785538 cites W1979645066 @default.
- W1505785538 cites W1982428356 @default.
- W1505785538 cites W1982889157 @default.
- W1505785538 cites W1983660540 @default.
- W1505785538 cites W1983706324 @default.
- W1505785538 cites W1984877838 @default.
- W1505785538 cites W1985237413 @default.
- W1505785538 cites W1987432599 @default.
- W1505785538 cites W1987528796 @default.
- W1505785538 cites W1987628941 @default.
- W1505785538 cites W1989378157 @default.
- W1505785538 cites W1991189614 @default.
- W1505785538 cites W1992993585 @default.
- W1505785538 cites W1993911530 @default.
- W1505785538 cites W1995556701 @default.
- W1505785538 cites W1997200668 @default.
- W1505785538 cites W1997254017 @default.
- W1505785538 cites W1998520631 @default.
- W1505785538 cites W1999476423 @default.
- W1505785538 cites W1999587083 @default.
- W1505785538 cites W2000793737 @default.
- W1505785538 cites W2002479123 @default.
- W1505785538 cites W2002637584 @default.
- W1505785538 cites W2003008123 @default.
- W1505785538 cites W2003762546 @default.
- W1505785538 cites W2004286315 @default.
- W1505785538 cites W2007167078 @default.
- W1505785538 cites W2008686801 @default.
- W1505785538 cites W2009597693 @default.
- W1505785538 cites W2010050518 @default.
- W1505785538 cites W2012855535 @default.
- W1505785538 cites W2014193054 @default.
- W1505785538 cites W2014373387 @default.
- W1505785538 cites W2014386715 @default.
- W1505785538 cites W2015112116 @default.
- W1505785538 cites W2015445474 @default.
- W1505785538 cites W2019640842 @default.
- W1505785538 cites W2019771665 @default.
- W1505785538 cites W2020651237 @default.
- W1505785538 cites W2023285758 @default.
- W1505785538 cites W2023501491 @default.
- W1505785538 cites W2024344682 @default.
- W1505785538 cites W2026740189 @default.
- W1505785538 cites W2027304084 @default.
- W1505785538 cites W2027914056 @default.
- W1505785538 cites W2027925098 @default.
- W1505785538 cites W2028980996 @default.
- W1505785538 cites W2029035280 @default.
- W1505785538 cites W2031130098 @default.
- W1505785538 cites W2031207403 @default.
- W1505785538 cites W2032044976 @default.
- W1505785538 cites W2033587421 @default.
- W1505785538 cites W2034051692 @default.
- W1505785538 cites W2035353363 @default.
- W1505785538 cites W2035399728 @default.
- W1505785538 cites W2035976682 @default.
- W1505785538 cites W2039158439 @default.
- W1505785538 cites W2042240426 @default.
- W1505785538 cites W2042479572 @default.
- W1505785538 cites W2042509585 @default.