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- W150585274 abstract "Hyperglycemia is a casual factor in the development of the vascular complications of diabetes. Vascular complications including impaired contractility and increased cell proliferation are frequently occurred in diabetes. Chronic hyperglycemia appears to be an important contributing factor to this process. The present study was designed to investigate the effect of Sasa borealis ethanol extract on chronic hyperglycemiainduced vascular endothelial dysfunction. HUVEC were cultured in 5.5 mM low-glucose, 5.5 mM glucose plus 27.5 mM mannitol as an osmotic control or 33 mM high glucose for 5 days with or without 10 μg/mL Sasa borealis extract. Cell survival of HUVEC treated with high glucose was markedly decreased relative to that with low glucose. Sasa borealis extract enhanced cell viability high glucose-treated HUVEC with reduction in reactive oxygen species detected by DCF-fluorescense. In addition, sustained hyperglycemia induced expression of endothelial nitric oxide synthase protein and mRNA as well as activation of protein kinase C. Sasa borealis extracts substantially suppressed these detrimental effects of high glucose on endothelial function. The results demonstrate that the improvement of endothelial dysfunction renders the blockade of Sasa borealis extracts a potential approach to the prevention and/or treatment of diabetic complications. Supported by Korea Science and Engineering Foundation (KOSEF R01-2003-000-10204-0)." @default.
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- W150585274 date "2006-03-01" @default.
- W150585274 modified "2023-10-16" @default.
- W150585274 title "Inhibitory effects of Sasa borealis extract on high glucose‐induced endothelial cell dysfunction and vascular complications" @default.
- W150585274 doi "https://doi.org/10.1096/fasebj.20.5.lb101-d" @default.
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