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- W1505869682 abstract "This chapter describes the immunohistochemical detection of estrogen receptor-binding fragment-associated gene 9/receptor-binding cancer antigen expressed on SiSo cells (EBAG9/RCAS1) expression in noncancerous liver tissue and in hepatocellular carcinoma (HCC) tissue, especially the methodologic aspects. In view of the pathologic features of HCC and the results of previous studies on EBAG9/RCAS1 as a cancer marker, the chapter discusses the multistep evolution of HCC, including (1) the process of tumor dedifferentiation, (2) cancer proliferative activity, and (3) ability to metastasize. EBAG9 is an estrogen-responsive gene that has been isolated from a CpG island library of MCF-7 human breast cancer cells by the genomic binding-site cloning method. The complementary DNA (cDNA) of human EBAG9 encodes an open reading frame of 213 amino acids. An estrogen-responsive element is located in the 5' flanking region of the EBAG9 gene, and its transcript is directly upregulated by estrogen. Based on in vitro observation, RCAS1 has been assumed to act as a ligand for a putative receptor present on normal peripheral lymphocytes, such as T, B, and natural killer cells." @default.
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- W1505869682 date "2005-01-01" @default.
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- W1505869682 title "Immunohistochemical Detection of EBAG9/RCAS1 Expression in Hepatocellular Carcinoma" @default.
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- W1505869682 doi "https://doi.org/10.1016/s1874-5784(05)80031-5" @default.
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