FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506070710> ?p ?o ?g. }

• W1506070710 endingPage "3307" @default.
• W1506070710 startingPage "3299" @default.
• W1506070710 abstract "Human immunodeficiency virus type 1 (HIV-1) infection is associated with loss of function and numbers of CD4+ T-helper cells. In order to bypass the requirement for CD4+ cells in antibody responses, we have utilized heat-inactivated Brucella abortus as a carrier. In this study we coupled a 14-mer V3 loop peptide (V3), which is homologous to 9 of 11 amino acids from the V3 loop of HIV-1 MN, and gp120 from HIV-1 SF2 to B. abortus [gp120(SF2)-B. abortus]. Our results showed that specific antibody responses, dominated by immunoglobulin G2a in BALB/c mice, were induced by these conjugates. Sera from the immunized mice bound native gp120 expressed on the surfaces of cells infected with a recombinant vaccinia virus gp160 vector (VPE16). Sera from mice immunized with gp120(SF2)-B. abortus inhibited binding of soluble CD4 to gp120, whereas sera from mice immunized with V3-B. abortus were ineffective. Sera from mice immunized with either conjugate were capable of blocking syncytium formation between CD4+ CEM cells and H9 cells chronically infected with the homologous virus. Sera from mice immunized with gp120(SF2)-B. abortus were more potent than sera from mice immunized with V3-B. abortus in inhibiting syncytia from heterologous HIV-1 laboratory strains. Importantly, in primary and secondary responses, V3-B. abortus evoked anti-HIV MN antibodies in mice depleted of CD4+ cells, and sera from these mice were able to inhibit syncytia. These findings indicate that B. abortus can provide carrier function for peptides and proteins from HIV-1 and suggest that they could be used for immunization of individuals with compromised CD4+ T-cell function." @default.
• W1506070710 created "2016-06-24" @default.
• W1506070710 creator A5013911638 @default.
• W1506070710 creator A5020973283 @default.
• W1506070710 creator A5037440173 @default.
• W1506070710 creator A5058300486 @default.
• W1506070710 creator A5062687328 @default.
• W1506070710 creator A5075780768 @default.
• W1506070710 creator A5076964371 @default.
• W1506070710 creator A5083185135 @default.
• W1506070710 date "1995-06-01" @default.
• W1506070710 modified "2023-09-27" @default.
• W1506070710 title "Brucella abortus conjugated with a gp120 or V3 loop peptide derived from human immunodeficiency virus (HIV) type 1 induces neutralizing anti-HIV antibodies, and the V3-B. abortus conjugate is effective even after CD4+ T-cell depletion" @default.
• W1506070710 cites W1521311909 @default.
• W1506070710 cites W1596243988 @default.
• W1506070710 cites W1673456927 @default.
• W1506070710 cites W1800390635 @default.
• W1506070710 cites W1809437764 @default.
• W1506070710 cites W1877738484 @default.
• W1506070710 cites W1966333025 @default.
• W1506070710 cites W1972385943 @default.
• W1506070710 cites W2024908512 @default.
• W1506070710 cites W2041647537 @default.
• W1506070710 cites W2047582417 @default.
• W1506070710 cites W2058990291 @default.
• W1506070710 cites W2073006935 @default.
• W1506070710 cites W2075854641 @default.
• W1506070710 cites W2097211121 @default.
• W1506070710 cites W2127278205 @default.
• W1506070710 cites W2135937013 @default.
• W1506070710 cites W2170389082 @default.
• W1506070710 cites W2172466148 @default.
• W1506070710 cites W3020963154 @default.
• W1506070710 doi "https://doi.org/10.1128/jvi.69.6.3299-3307.1995" @default.
• W1506070710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189041" @default.
• W1506070710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7745677" @default.
• W1506070710 hasPublicationYear "1995" @default.
• W1506070710 type Work @default.
• W1506070710 sameAs 1506070710 @default.
• W1506070710 citedByCount "28" @default.
• W1506070710 countsByYear W15060707102013 @default.
• W1506070710 crossrefType "journal-article" @default.
• W1506070710 hasAuthorship W1506070710A5013911638 @default.
• W1506070710 hasAuthorship W1506070710A5020973283 @default.
• W1506070710 hasAuthorship W1506070710A5037440173 @default.
• W1506070710 hasAuthorship W1506070710A5058300486 @default.
• W1506070710 hasAuthorship W1506070710A5062687328 @default.
• W1506070710 hasAuthorship W1506070710A5075780768 @default.
• W1506070710 hasAuthorship W1506070710A5076964371 @default.
• W1506070710 hasAuthorship W1506070710A5083185135 @default.
• W1506070710 hasBestOaLocation W15060707101 @default.
• W1506070710 hasConcept C104317684 @default.
• W1506070710 hasConcept C153911025 @default.
• W1506070710 hasConcept C159047783 @default.
• W1506070710 hasConcept C159654299 @default.
• W1506070710 hasConcept C195616568 @default.
• W1506070710 hasConcept C203014093 @default.
• W1506070710 hasConcept C2522874641 @default.
• W1506070710 hasConcept C2779921545 @default.
• W1506070710 hasConcept C2780115692 @default.
• W1506070710 hasConcept C40479148 @default.
• W1506070710 hasConcept C55493867 @default.
• W1506070710 hasConcept C86803240 @default.
• W1506070710 hasConcept C89423630 @default.
• W1506070710 hasConceptScore W1506070710C104317684 @default.
• W1506070710 hasConceptScore W1506070710C153911025 @default.
• W1506070710 hasConceptScore W1506070710C159047783 @default.
• W1506070710 hasConceptScore W1506070710C159654299 @default.
• W1506070710 hasConceptScore W1506070710C195616568 @default.
• W1506070710 hasConceptScore W1506070710C203014093 @default.
• W1506070710 hasConceptScore W1506070710C2522874641 @default.
• W1506070710 hasConceptScore W1506070710C2779921545 @default.
• W1506070710 hasConceptScore W1506070710C2780115692 @default.
• W1506070710 hasConceptScore W1506070710C40479148 @default.
• W1506070710 hasConceptScore W1506070710C55493867 @default.
• W1506070710 hasConceptScore W1506070710C86803240 @default.
• W1506070710 hasConceptScore W1506070710C89423630 @default.
• W1506070710 hasIssue "6" @default.
• W1506070710 hasLocation W15060707101 @default.
• W1506070710 hasLocation W15060707102 @default.
• W1506070710 hasLocation W15060707103 @default.
• W1506070710 hasLocation W15060707104 @default.
• W1506070710 hasOpenAccess W1506070710 @default.
• W1506070710 hasPrimaryLocation W15060707101 @default.
• W1506070710 hasRelatedWork W1487857142 @default.
• W1506070710 hasRelatedWork W1584532949 @default.
• W1506070710 hasRelatedWork W1973614011 @default.
• W1506070710 hasRelatedWork W2062279822 @default.
• W1506070710 hasRelatedWork W2091214500 @default.
• W1506070710 hasRelatedWork W2094309210 @default.
• W1506070710 hasRelatedWork W2134401158 @default.
• W1506070710 hasRelatedWork W2147040603 @default.
• W1506070710 hasRelatedWork W2152981376 @default.
• W1506070710 hasRelatedWork W103139932 @default.
• W1506070710 hasVolume "69" @default.
• W1506070710 isParatext "false" @default.
• W1506070710 isRetracted "false" @default.
• W1506070710 magId "1506070710" @default.

• next