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- W1506083934 abstract "This chapter describes the Ras activation of NF- K B and superoxide. p21 ras (c-Ras) participates in various cellular processes, including proliferation, differentiation, apoptosis, and cytoskeletal organization. Mutations in a ras allele that render it constitutively active have been described in approximately 30% of all human tumors, making it the most widely mutated human protooncogene. NF- K B is a transcription factor that regulates genes involved in immune and inflammatory responses, cell proliferation, differentiation, and apoptosis. There are five members in the NF- K B family: p50/ NF- K B 1, p52/ NF- K B 2, RelA/p65, RelB, and c-RelY. The Rel homology domain found in each of these proteins functions in DNA binding, dimerization among family members, and interaction with a family of inhibitory proteins known as I- K B, including 1- K B α and I- K Bβ, which bind to NF- K B and sequester it in the cytoplasm. Previously, Rac activation assay involved the use of the radioisotope 32 P. The chapter adopted a nonradioisotope protocol developed by Upstate Biotechnology, Inc. to detect Rac activation." @default.
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- W1506083934 date "2001-01-01" @default.
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- W1506083934 title "Ras activation of NF-κB and superoxide" @default.
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- W1506083934 doi "https://doi.org/10.1016/s0076-6879(01)33047-1" @default.
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