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- W1506231842 abstract "Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New Zealand (Oryctolagus cuniculus huxley) rabbits. Twenty rabbits were used; each of the two groups (hypothyroidism and control) consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks. The mean values of Triiodothyronine (T3), thyroxine (T4), free T3 (FT3) and free T4(FT4) were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl, 2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and 0.18±0.11p mol/dl in the hypothyroidism group, respectively (p<0.05 for all). Levels of total plasma triglyseride (TG), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and apolipoprotein-B (Apo-B) were recorded as 44.2±8.57, 12.2±2.7, 40.4±14.9 and 87.2±15.2 mg.dl -1 in the control group, and 97.9±29.8, 23.2±2.9, 67.2±13.5 and 147.4±55.7 mg.dl -1 in the hypothyroidism group, respectively (p<0.001 for all parameters). The results showed that T3, T4, FT3 and FT4 decreased in the hypothyroidism group, but lipid fractions were higher than in the control group. In addition, a significant negative correlation was found between T4-TC (r=-0.739, p<0.05) and T4-Apo-B (r=-0.666, p<0.05). Deney sonunda kontrol grubu hayvanlarin (T 3 ), (T 4 ), FT 3 ve FT 4 deerleri sirasiyla 121.7±32.7 ng/dl, 1.81±0.60 µg/dl, 2.36±0.92 ng/dl, 0.43±0.22 p mol/dl iken hipotiroidili hayvanlarda 88.4±19.2 ng/dl, 1.15±037 µ/dl, 1.48±0.44 ng/dl, 0.18±0.11p mol/dl idi (p<0.05). Ayrica, plazma total TG, HDL-C, TC ve Apo-B seviyelerinin ise, kontrol grubunda sirasiyla 44.2±8.57, 12.2±2.7, 40.4±14.9, 87.2±15.2 mg.dl -1 , hipotiroidi grubunda 97.9±29.8, 23.2±2.9, 67.2±13.5, 147.4±55.7 mg.dl -1 olduu belirlendi (tum parametreler icin; p<0.001). Sonuclar gosterdi ki, hipotiroidizmde T 3 , T 4 , FT 3 ve FT 4 deerleri azalmifltir. Ayrica T 4 -TC (- 0.739, p<0.05) ve T 4 -Apo-B(-0.666, p<0.05) arasinda onemli oranda negatif iliflki bulunmufltur." @default.
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- W1506231842 date "2000-04-19" @default.
- W1506231842 modified "2023-09-23" @default.
- W1506231842 title "Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits" @default.
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