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- W1506305336 endingPage "113" @default.
- W1506305336 startingPage "93" @default.
- W1506305336 abstract "Recent advances in biotechnology and the increasingly availability of proteins and of peptides with potential therapeutic applications have generated a renewed necessity for the controlled delivery of this class of macromolecules. Due to their large size and hydrophilic nature, these proteins and peptides are incapable of permeating cellular membranes without the assistance of specific cell-membrane transporters or carriers. Although cellular uptake of proteins is dependent upon endocytosis, passage through endothelial and epithelial barriers, i.e., transcytosis, will govern delivery from the site of administration to the site of action. The transport of proteins can be achieved by either modification of the native protein or attachment to receptor-specific or membrane-adsorptive carrier molecules. The design of an effective macromolecular drug carrier system requires an understanding of these intricate cellular transport and processing mechanisms. In some cases these processes can be manipulated in a pharmacological manner in order to improve significantly their transport. The exploitation of endocytotic and transcytotic processes is likely to become useful for the delivery of therapeutic proteins as well as other desirable macromolecules." @default.
- W1506305336 created "2016-06-24" @default.
- W1506305336 creator A5002688929 @default.
- W1506305336 creator A5047415745 @default.
- W1506305336 creator A5064684441 @default.
- W1506305336 date "1992-01-01" @default.
- W1506305336 modified "2023-10-18" @default.
- W1506305336 title "(C) Means to enhance penetration" @default.
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- W1506305336 doi "https://doi.org/10.1016/0169-409x(92)90016-j" @default.