FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506388624> ?p ?o ?g. }

• W1506388624 endingPage "825" @default.
• W1506388624 startingPage "817" @default.
• W1506388624 abstract "Perfusion MRI has the potential to provide pathophysiological biomarkers for the evaluating, staging and therapy monitoring of prostate cancer. The objective of this study was to explore the feasibility of noninvasive arterial spin labeling (ASL) to detect prostate cancer in the peripheral zone and to investigate the correlation between the blood flow (BF) measured by ASL and the pharmacokinetic parameters K trans (forward volume transfer constant), k ep (reverse reflux rate constant between extracellular space and plasma) and v e (the fractional volume of extracellular space per unit volume of tissue) measured by dynamic contrast‐enhanced (DCE) MRI in patients with prostate cancer. Forty‐three consecutive patients (ages ranging from 49 to 86 years, with a median age of 74 years) with pathologically confirmed prostate cancer were recruited. An ASL scan with four different inversion times (TI = 1000, 1200, 1400 and 1600 ms) and a DCE‐MRI scan were performed on a clinical 3.0 T GE scanner. BF, K trans , k ep and v e maps were calculated. In order to determine whether the BF values in the cancerous area were statistically different from those in the noncancerous area, an independent t ‐test was performed. Spearman's bivariate correlation was used to assess the relationship between BF and the pharmacokinetic parameters K trans , k ep and v e . The mean BF values in the cancerous areas (97.1 ± 30.7, 114.7 ± 28.7, 102.3 ± 22.5, 91.2 ± 24.2 ml/100 g/min, respectively, for TI = 1000, 1200, 1400, 1600 ms) were significantly higher ( p < 0.01 for all cases) than those in the noncancerous regions (35.8 ± 12.5, 42.2 ± 13.7, 53.5 ± 19.1, 48.5 ± 13.5 ml/100 g/min, respectively). Significant positive correlations ( p < 0.01 for all cases) between BF and the pharmacokinetic parameters K trans , k ep and v e were also observed for all four TI values ( r = 0.671, 0.407, 0.666 for TI = 1000 ms; 0.713, 0.424, 0.698 for TI = 1200 ms; 0.604, 0.402, 0.595 for TI = 1400 ms; 0.605, 0.422, 0.548 for TI = 1600 ms). It can be seen that the quantitative ASL measurements show significant differences between cancerous and benign tissues, and exhibit strong to moderate correlations with the parameters obtained using DCE‐MRI. These results show the promise of ASL as a noninvasive alternative to DCE‐MRI. Copyright © 2014 John Wiley & Sons, Ltd." @default.
• W1506388624 created "2016-06-24" @default.
• W1506388624 creator A5010385452 @default.
• W1506388624 creator A5026217018 @default.
• W1506388624 creator A5028178244 @default.
• W1506388624 creator A5029363724 @default.
• W1506388624 creator A5037677450 @default.
• W1506388624 creator A5044870059 @default.
• W1506388624 creator A5075090550 @default.
• W1506388624 creator A5090789982 @default.
• W1506388624 date "2014-05-09" @default.
• W1506388624 modified "2023-10-13" @default.
• W1506388624 title "A comparison of arterial spin labeling perfusion MRI and DCE‐MRI in human prostate cancer" @default.
• W1506388624 cites W1563825794 @default.
• W1506388624 cites W1896502062 @default.
• W1506388624 cites W1963622760 @default.
• W1506388624 cites W1964786683 @default.
• W1506388624 cites W1967384378 @default.
• W1506388624 cites W1970489302 @default.
• W1506388624 cites W1970606486 @default.
• W1506388624 cites W1970638085 @default.
• W1506388624 cites W1972977795 @default.
• W1506388624 cites W1978139448 @default.
• W1506388624 cites W1985261403 @default.
• W1506388624 cites W1985528986 @default.
• W1506388624 cites W1989854445 @default.
• W1506388624 cites W1995388230 @default.
• W1506388624 cites W1995499810 @default.
• W1506388624 cites W2009638349 @default.
• W1506388624 cites W2010796934 @default.
• W1506388624 cites W2013438136 @default.
• W1506388624 cites W2019190989 @default.
• W1506388624 cites W2021496866 @default.
• W1506388624 cites W2034269086 @default.
• W1506388624 cites W2042098439 @default.
• W1506388624 cites W2045372886 @default.
• W1506388624 cites W2050386888 @default.
• W1506388624 cites W2053625830 @default.
• W1506388624 cites W2054633472 @default.
• W1506388624 cites W2059283030 @default.
• W1506388624 cites W2072716050 @default.
• W1506388624 cites W2088002109 @default.
• W1506388624 cites W2089513130 @default.
• W1506388624 cites W2091177568 @default.
• W1506388624 cites W2091861364 @default.
• W1506388624 cites W2092566521 @default.
• W1506388624 cites W2095909624 @default.
• W1506388624 cites W2098221867 @default.
• W1506388624 cites W2100488793 @default.
• W1506388624 cites W2102564020 @default.
• W1506388624 cites W2106787323 @default.
• W1506388624 cites W2121396315 @default.
• W1506388624 cites W2124539070 @default.
• W1506388624 cites W2125174047 @default.
• W1506388624 cites W2129589381 @default.
• W1506388624 cites W2147816079 @default.
• W1506388624 cites W2149953389 @default.
• W1506388624 cites W2160223041 @default.
• W1506388624 cites W2166544843 @default.
• W1506388624 cites W2167565818 @default.
• W1506388624 cites W2168932357 @default.
• W1506388624 cites W2331113209 @default.
• W1506388624 cites W2424287956 @default.
• W1506388624 cites W2804842145 @default.
• W1506388624 doi "https://doi.org/10.1002/nbm.3124" @default.
• W1506388624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24809332" @default.
• W1506388624 hasPublicationYear "2014" @default.
• W1506388624 type Work @default.
• W1506388624 sameAs 1506388624 @default.
• W1506388624 citedByCount "17" @default.
• W1506388624 countsByYear W15063886242015 @default.
• W1506388624 countsByYear W15063886242016 @default.
• W1506388624 countsByYear W15063886242018 @default.
• W1506388624 countsByYear W15063886242019 @default.
• W1506388624 countsByYear W15063886242020 @default.
• W1506388624 countsByYear W15063886242021 @default.
• W1506388624 countsByYear W15063886242022 @default.
• W1506388624 countsByYear W15063886242023 @default.
• W1506388624 crossrefType "journal-article" @default.
• W1506388624 hasAuthorship W1506388624A5010385452 @default.
• W1506388624 hasAuthorship W1506388624A5026217018 @default.
• W1506388624 hasAuthorship W1506388624A5028178244 @default.
• W1506388624 hasAuthorship W1506388624A5029363724 @default.
• W1506388624 hasAuthorship W1506388624A5037677450 @default.
• W1506388624 hasAuthorship W1506388624A5044870059 @default.
• W1506388624 hasAuthorship W1506388624A5075090550 @default.
• W1506388624 hasAuthorship W1506388624A5090789982 @default.
• W1506388624 hasConcept C112705442 @default.
• W1506388624 hasConcept C121608353 @default.
• W1506388624 hasConcept C126322002 @default.
• W1506388624 hasConcept C126838900 @default.
• W1506388624 hasConcept C143409427 @default.
• W1506388624 hasConcept C146957229 @default.
• W1506388624 hasConcept C185592680 @default.
• W1506388624 hasConcept C2113261 @default.
• W1506388624 hasConcept C2776235491 @default.
• W1506388624 hasConcept C2780192828 @default.
• W1506388624 hasConcept C28406088 @default.

• next