FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506421429> ?p ?o ?g. }

• W1506421429 endingPage "3787" @default.
• W1506421429 startingPage "3781" @default.
• W1506421429 abstract "Abstract We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)–induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycylarginyl chloromethyl ketone–treated factor Xa (DEGR-FXa; active-site–blocked factor Xa), heparin or diisopropyl fluorophosphate–treated APC (DIP-APC; inactive derivative of ARC) had no effect. Furthermore, APC significantly inhibited the I/R-induced decrease in renal tissue blood flow and the increase in the vascular permeability, whereas neither DEGR-FXa, heparin, nor DIP-APC produced such effects. Renal I/R-induced increases in plasma levels of fibrin degradation products were significantly inhibited by APC, DEGR-FXa, and heparin. These observations suggest that APC reduces I/R-induced renal injury independently of its anticoagulant effects but in a manner dependent on its serine protease activity. Renal levels of tumor necrosis factor- (TNF-), rat interleukin-8, and myeloperoxidase were significantly increased after renal I/R. These increases were significantly inhibited by APC but not by DEGR-FXa, heparin, or DIP-APC. Leukocytopenia produced effects similar to those of APC. These findings strongly suggest that APC protects against I/R-induced renal injury not by inhibiting coagulation abnormalities but by inhibiting activation of leukocytes that play an important role in I/R-induced renal injury. Inhibition of leukocyte activation by APC could be explained by the inhibitory activity of TNF-." @default.
• W1506421429 created "2016-06-24" @default.
• W1506421429 creator A5004481674 @default.
• W1506421429 creator A5070002300 @default.
• W1506421429 creator A5074068422 @default.
• W1506421429 creator A5081500257 @default.
• W1506421429 date "2000-06-15" @default.
• W1506421429 modified "2023-10-01" @default.
• W1506421429 title "Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation" @default.
• W1506421429 cites W1483113783 @default.
• W1506421429 cites W1522778435 @default.
• W1506421429 cites W1562824675 @default.
• W1506421429 cites W1978558290 @default.
• W1506421429 cites W2021483318 @default.
• W1506421429 cites W2037270127 @default.
• W1506421429 cites W2039697569 @default.
• W1506421429 cites W2042168975 @default.
• W1506421429 cites W2044252321 @default.
• W1506421429 cites W2046149192 @default.
• W1506421429 cites W2051354793 @default.
• W1506421429 cites W2063123103 @default.
• W1506421429 cites W2067709564 @default.
• W1506421429 cites W2070892241 @default.
• W1506421429 cites W2074044112 @default.
• W1506421429 cites W2087968228 @default.
• W1506421429 cites W2100994529 @default.
• W1506421429 cites W2112348962 @default.
• W1506421429 cites W2133575487 @default.
• W1506421429 cites W2134903524 @default.
• W1506421429 cites W2164492572 @default.
• W1506421429 cites W2396570129 @default.
• W1506421429 cites W2404171958 @default.
• W1506421429 cites W2404848933 @default.
• W1506421429 cites W2412312642 @default.
• W1506421429 cites W314977035 @default.
• W1506421429 cites W4236514815 @default.
• W1506421429 doi "https://doi.org/10.1182/blood.v95.12.3781" @default.
• W1506421429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845910" @default.
• W1506421429 hasPublicationYear "2000" @default.
• W1506421429 type Work @default.
• W1506421429 sameAs 1506421429 @default.
• W1506421429 citedByCount "162" @default.
• W1506421429 countsByYear W15064214292012 @default.
• W1506421429 countsByYear W15064214292013 @default.
• W1506421429 countsByYear W15064214292014 @default.
• W1506421429 countsByYear W15064214292015 @default.
• W1506421429 countsByYear W15064214292017 @default.
• W1506421429 countsByYear W15064214292019 @default.
• W1506421429 countsByYear W15064214292022 @default.
• W1506421429 crossrefType "journal-article" @default.
• W1506421429 hasAuthorship W1506421429A5004481674 @default.
• W1506421429 hasAuthorship W1506421429A5070002300 @default.
• W1506421429 hasAuthorship W1506421429A5074068422 @default.
• W1506421429 hasAuthorship W1506421429A5081500257 @default.
• W1506421429 hasConcept C126322002 @default.
• W1506421429 hasConcept C134018914 @default.
• W1506421429 hasConcept C144594695 @default.
• W1506421429 hasConcept C181199279 @default.
• W1506421429 hasConcept C185592680 @default.
• W1506421429 hasConcept C186738567 @default.
• W1506421429 hasConcept C203014093 @default.
• W1506421429 hasConcept C203565725 @default.
• W1506421429 hasConcept C2776714187 @default.
• W1506421429 hasConcept C2776914184 @default.
• W1506421429 hasConcept C2777557582 @default.
• W1506421429 hasConcept C2777807008 @default.
• W1506421429 hasConcept C2778382381 @default.
• W1506421429 hasConcept C2780091579 @default.
• W1506421429 hasConcept C2781287897 @default.
• W1506421429 hasConcept C55493867 @default.
• W1506421429 hasConcept C71924100 @default.
• W1506421429 hasConcept C98274493 @default.
• W1506421429 hasConceptScore W1506421429C126322002 @default.
• W1506421429 hasConceptScore W1506421429C134018914 @default.
• W1506421429 hasConceptScore W1506421429C144594695 @default.
• W1506421429 hasConceptScore W1506421429C181199279 @default.
• W1506421429 hasConceptScore W1506421429C185592680 @default.
• W1506421429 hasConceptScore W1506421429C186738567 @default.
• W1506421429 hasConceptScore W1506421429C203014093 @default.
• W1506421429 hasConceptScore W1506421429C203565725 @default.
• W1506421429 hasConceptScore W1506421429C2776714187 @default.
• W1506421429 hasConceptScore W1506421429C2776914184 @default.
• W1506421429 hasConceptScore W1506421429C2777557582 @default.
• W1506421429 hasConceptScore W1506421429C2777807008 @default.
• W1506421429 hasConceptScore W1506421429C2778382381 @default.
• W1506421429 hasConceptScore W1506421429C2780091579 @default.
• W1506421429 hasConceptScore W1506421429C2781287897 @default.
• W1506421429 hasConceptScore W1506421429C55493867 @default.
• W1506421429 hasConceptScore W1506421429C71924100 @default.
• W1506421429 hasConceptScore W1506421429C98274493 @default.
• W1506421429 hasIssue "12" @default.
• W1506421429 hasLocation W15064214291 @default.
• W1506421429 hasLocation W15064214292 @default.
• W1506421429 hasOpenAccess W1506421429 @default.
• W1506421429 hasPrimaryLocation W15064214291 @default.
• W1506421429 hasRelatedWork W1506421429 @default.
• W1506421429 hasRelatedWork W1819870217 @default.
• W1506421429 hasRelatedWork W1969782629 @default.

• next