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• W1506441375 abstract "Quantitative estimation of poorly water-soluble drugs involves use of organic solvents. Major drawbacks of organic solvents include high cost, volatility and toxicity. In the present investigation, hydrotropic solubilization is employed to enhance the aqueous solubilities of poorly water-soluble drugs metronidazole and miconazole nitrate in two-component pharmaceutical formulations for simultaneous spectrophotometric determination. Three novel, simple, accurate, sensitive and economical procedures employed are simultaneous equation method, absorbance ratio method, and dual wavelength method. All methods utilize solution containing 40% urea and 10% sodium benzoateas, hydrotropic solubilizing agent. The solubility of drugs increases more than 14 times in mixed hydrotropic solution as compared to solubility in distilled water.In the solution containing 40% urea and 10% sodium benzoate, metronidazole and miconazole nitrate show maximum absorbance at a wavelength of about 325&285 nm respectively and isobestic point is observed at 296 nm. The results of analysis have been validated statistically and by recovery studies. Parameters such as linearity, precision, accuracy, specificity and robustness were studied as reported in the International Conference on Harmonization guidelines. So this method can be successfully employed in the routine analysis of metronidazole and miconazole nitrate in bulk drug and dosage forms like ovules and gel." @default.
• W1506441375 created "2016-06-24" @default.
• W1506441375 creator A5030713234 @default.
• W1506441375 date "2012-01-01" @default.
• W1506441375 modified "2023-09-28" @default.
• W1506441375 title "Application of Mixed Hydrotropic Solubilization Technique for Simultaneous Spectrophotometric Estimation of Metronidazole and Miconazole Nitrate from Different Pharmaceutical Dosage Forms" @default.
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