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- W1506457066 abstract "Abstract The ability of mouse thymus-dependent (T) and bone marrow-derived (B) lymphocytes to cooperate in the (humoral) rejection of the rat Yoshida ascites sarcoma (YAS) was investigated. Mice of two hybrid constitutions that had one parent of the same strain and the other of a different strain were used. T and B cells thus shared one haplotype of the transplantation genes, but the other haplotype was different so that allogeneic recognition could take place in both directions. To investigate the influence of allogeneic recognition on T-B cell cooperation, mice were also made mutually tolerant by establishing long-term radiation chimeras. Erythrocytes and spleen cells of the chimera were shown by serologic analysis to be donor-type. When the chimera was to serve as tumor host and B cell source, it was thymectomized before irradiation and reconstitution with Thy 1.2 antisera and complement-treated bone marrow (TIR). The evidence of tolerance was markedly reduced anti-host-type reactivity in short-term in vivo [3H]thymidine uptake studies. Successful cooperation, manifested by YAS rejection in TIR mice given splenic T cells, was seen a) whenever the transferred T cells and the cells of the TIR recipient were syngeneic, and b) when the T cells were nonsyngeneic with the cells in TIR recipients but were obtained from chimeric donors and injected into chimeric recipients. Chimerism of only T cell donors or TIR recipients was not sufficient for YAS rejection to be induced. The data suggest that the allogeneic recognition on either T or B lymphocytes may thwart otherwise successful cell cooperation." @default.
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- W1506457066 date "1979-03-01" @default.
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- W1506457066 title "<i>in Vivo</i> Cooperation of Murine Lymphocytes Sharing One Haplotype of the Transplantation Genes: A Requirement for Tolerance of the Nonshared Haplotype" @default.
- W1506457066 doi "https://doi.org/10.4049/jimmunol.122.3.1116" @default.
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