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- W1506490676 abstract "Acute regional myocardial ischemia can lead to re-entrant activity under certain circumstances. Electrophysiological inhomogeneities within the tissue concomitant with premature stimuli may cause a specific type of re-entry called re-entry. We reproduced and analysed the patterns of electrical activation in a 2D sheet of regionally-ischemic myocardial tissue using computer modeling. Simulations were carried out using a modified version of the Luo-Rudy-II model (C.H. Luo & Y. Rudy, 1994), which included a formulation of I/sub K(ATP)/ by J.M. Ferrero et al. (1996). The simulated 2D tissue included a central ischemic zone, a border zone and a normal zone. Our results showed differences in action potential and conduction velocity within the tissue, leading to curved patterns of activation and figure-of-eight re-entries. The vulnerable window, i.e. the time interval of the re-entrant premature stimulus, was wider under anisotropic conditions than in an isotropic tissue." @default.
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- W1506490676 date "2002-11-13" @default.
- W1506490676 modified "2023-09-25" @default.
- W1506490676 title "Patterns of electrical activation in an inhomogeneous ischemic sheet of myocardial tissue: a simulation study" @default.
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- W1506490676 doi "https://doi.org/10.1109/cic.2001.977668" @default.
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