Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506536175> ?p ?o ?g. }
- W1506536175 abstract "A close association between salt-sensitive hypertension and insulin resistance has been recognized for more than two decades, although the mechanism(s) underlying this relationship have not been elucidated. Recent data in mice with genetic disruption of the gamma-melanocyte-stimulating hormone (gamma-MSH) system suggest that this system plays a role in the pathophysiological relationship between hypertension and altered glucose metabolism during ingestion of a high-sodium diet (8% NaCl, HSD). We tested the hypothesis that these two consequences of interrupted gamma-MSH signalling were the result of sympathetic activation by studying rats treated with the dopaminergic agonist bromocriptine (5 mg kg(-1) i.p., daily for 1 week; Bromo) to cause relative gamma-MSH deficiency. Bromo-treated rats fed the HSD developed hypertension and also exhibited fasting hyperglycaemia (P < 0.005) and hyperinsulinaemia (P < 0.025). Furthermore, Bromo-treated rats on the HSD had impaired glucose tolerance and blunted insulin-mediated glucose disposal. Intravenous infusion of gamma(2)-MSH, or of the alpha-adrenergic receptor antagonist phentolamine, to Bromo-HSD rats lowered both mean arterial pressure (MAP) and blood glucose to normal after 15 min (P < 0.001 versus control), but had no effect in rats receiving vehicle and fed the HSD; gamma(2)-MSH infusion also reduced the elevated plasma noradrenaline to control levels in parallel with the reductions in MAP and blood glucose concentration. Infusion of hydralazine to Bromo-HSD rats lowered MAP but had only a trivial effect on blood glucose. We conclude that rats with relative gamma-MSH deficiency develop abnormal glucose metabolism, with features of insulin resistance, in association with hypertension when ingesting the HSD. Elevated plasma noradrenaline concentration in Bromo-HSD rats is normalized by gamma(2)-MSH infusion, suggesting that an adrenergic mechanism may link the salt-sensitive hypertension and the impaired glucose metabolism of relative gamma-MSH deficiency." @default.
- W1506536175 created "2016-06-24" @default.
- W1506536175 creator A5017368237 @default.
- W1506536175 creator A5049762744 @default.
- W1506536175 creator A5074452727 @default.
- W1506536175 creator A5074500898 @default.
- W1506536175 date "2009-07-13" @default.
- W1506536175 modified "2023-09-27" @default.
- W1506536175 title "Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of γ-melanocyte-stimulating hormone" @default.
- W1506536175 cites W1605254640 @default.
- W1506536175 cites W1964628464 @default.
- W1506536175 cites W1966752541 @default.
- W1506536175 cites W1970993456 @default.
- W1506536175 cites W1979395838 @default.
- W1506536175 cites W1991957531 @default.
- W1506536175 cites W1992609447 @default.
- W1506536175 cites W2003506060 @default.
- W1506536175 cites W2004192853 @default.
- W1506536175 cites W2006884514 @default.
- W1506536175 cites W2013165673 @default.
- W1506536175 cites W2020166661 @default.
- W1506536175 cites W2024726824 @default.
- W1506536175 cites W2033132953 @default.
- W1506536175 cites W2034778102 @default.
- W1506536175 cites W2040500100 @default.
- W1506536175 cites W2047771556 @default.
- W1506536175 cites W2060521806 @default.
- W1506536175 cites W2063177190 @default.
- W1506536175 cites W2065292451 @default.
- W1506536175 cites W2074515261 @default.
- W1506536175 cites W2090129550 @default.
- W1506536175 cites W2096860809 @default.
- W1506536175 cites W2103235855 @default.
- W1506536175 cites W2130087327 @default.
- W1506536175 cites W2133399721 @default.
- W1506536175 cites W2136994128 @default.
- W1506536175 cites W2139446059 @default.
- W1506536175 cites W2152645306 @default.
- W1506536175 cites W2154055479 @default.
- W1506536175 cites W2168817146 @default.
- W1506536175 cites W2168971224 @default.
- W1506536175 cites W2319850088 @default.
- W1506536175 cites W2463982268 @default.
- W1506536175 cites W4234513605 @default.
- W1506536175 doi "https://doi.org/10.1113/expphysiol.2009.046748" @default.
- W1506536175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2853237" @default.
- W1506536175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19429645" @default.
- W1506536175 hasPublicationYear "2009" @default.
- W1506536175 type Work @default.
- W1506536175 sameAs 1506536175 @default.
- W1506536175 citedByCount "2" @default.
- W1506536175 crossrefType "journal-article" @default.
- W1506536175 hasAuthorship W1506536175A5017368237 @default.
- W1506536175 hasAuthorship W1506536175A5049762744 @default.
- W1506536175 hasAuthorship W1506536175A5074452727 @default.
- W1506536175 hasAuthorship W1506536175A5074500898 @default.
- W1506536175 hasBestOaLocation W15065361751 @default.
- W1506536175 hasConcept C126322002 @default.
- W1506536175 hasConcept C134018914 @default.
- W1506536175 hasConcept C170493617 @default.
- W1506536175 hasConcept C17093226 @default.
- W1506536175 hasConcept C2777391703 @default.
- W1506536175 hasConcept C2779306644 @default.
- W1506536175 hasConcept C2780253649 @default.
- W1506536175 hasConcept C71315377 @default.
- W1506536175 hasConcept C71924100 @default.
- W1506536175 hasConceptScore W1506536175C126322002 @default.
- W1506536175 hasConceptScore W1506536175C134018914 @default.
- W1506536175 hasConceptScore W1506536175C170493617 @default.
- W1506536175 hasConceptScore W1506536175C17093226 @default.
- W1506536175 hasConceptScore W1506536175C2777391703 @default.
- W1506536175 hasConceptScore W1506536175C2779306644 @default.
- W1506536175 hasConceptScore W1506536175C2780253649 @default.
- W1506536175 hasConceptScore W1506536175C71315377 @default.
- W1506536175 hasConceptScore W1506536175C71924100 @default.
- W1506536175 hasLocation W15065361751 @default.
- W1506536175 hasLocation W15065361752 @default.
- W1506536175 hasLocation W15065361753 @default.
- W1506536175 hasLocation W15065361754 @default.
- W1506536175 hasOpenAccess W1506536175 @default.
- W1506536175 hasPrimaryLocation W15065361751 @default.
- W1506536175 hasRelatedWork W1968430244 @default.
- W1506536175 hasRelatedWork W1976109981 @default.
- W1506536175 hasRelatedWork W1979022888 @default.
- W1506536175 hasRelatedWork W1991957531 @default.
- W1506536175 hasRelatedWork W2001874361 @default.
- W1506536175 hasRelatedWork W2007867315 @default.
- W1506536175 hasRelatedWork W2008353837 @default.
- W1506536175 hasRelatedWork W2011916347 @default.
- W1506536175 hasRelatedWork W2049369483 @default.
- W1506536175 hasRelatedWork W2050804711 @default.
- W1506536175 hasRelatedWork W2054125205 @default.
- W1506536175 hasRelatedWork W2068232494 @default.
- W1506536175 hasRelatedWork W2070908628 @default.
- W1506536175 hasRelatedWork W2077359837 @default.
- W1506536175 hasRelatedWork W2078020390 @default.
- W1506536175 hasRelatedWork W2100624249 @default.
- W1506536175 hasRelatedWork W2143865199 @default.
- W1506536175 hasRelatedWork W2150355182 @default.
- W1506536175 hasRelatedWork W2417766263 @default.