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- W1506576730 abstract "This chapter focuses on the critical analysis of tumor suppressor p53 mutations and breast cancer. Cancer of the breast is the most common neoplasm and the leading cause of cancer-related deaths among women in most developed and many developing countries. Risk factors associated with the disease include both personal and environmental sources comprising a family history of cancer, higher socioeconomic class, first childbirth after the age of 25, early age of menarche, late age of menopause, and high dietary fat intake. The exact effect of p53-mediated growth suppression seems to be cell-type specific but appears to be directly related to the ability of p53 to act as a specific transcriptional activator. The role that transcriptional repression plays in the function of wild-type (WT) p53 is less clear. It is also possible that p53 has a more direct activity in deoxyribonucleic acid (DNA) replication and repair. Most documented p53 mutations result in single amino acid substitutions, which may confer one or more of a spectrum of transforming abilities on the protein. Mutation may lead to nuclear accumulation of p53 protein; however, inactivation of p53 by nuclear exclusion and interaction with the murine double minute 2 (mdm2) protein also appear to be important in tumorigenesis. A syngeneic mouse model system yielded evidence that p53 mutations are important in the early, preneoplastic stages of mammary tumorigenesis. This murine system may provide the ability to investigate the functions of p53 in the early stages of breast cancer, which are technically difficult to examine in the human system." @default.
- W1506576730 created "2016-06-24" @default.
- W1506576730 creator A5011407443 @default.
- W1506576730 creator A5076330048 @default.
- W1506576730 date "1995-01-01" @default.
- W1506576730 modified "2023-10-16" @default.
- W1506576730 title "Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis" @default.
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