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• W1506579269 abstract "Summary While much is known about tolerogenic dendritic cell effects on forkhead box protein 3 (FoxP3)+ regulatory T cells, virtually nothing is known about their effects on another arm of immunoregulation that is mediated by a subpopulation of immunosuppressive B cells. These cells suppress rheumatoid arthritis, lupus and inflammatory bowel disease in mice, and functional defects have been reported in human lupus. We show that co-stimulation-impaired tolerogenic dendritic cells that prevent and reverse type 1 diabetes mellitus induce the proliferation of human immunosuppressive B cells in vitro. We also show that the suppressive properties of these B cells concentrate inside the CD19+CD24+ B cell population and more specifically inside the CD19+CD24+CD38+ regulatory B cell population. We discovered that B cell conversion into suppressive cells in vitro is partially dependent on dendritic cell production of retinoic acid and also that CD19+CD24+CD38+ B regulatory cells express retinoic acid receptors. Taken together, our data suggest a model whereby part of the immunosuppressive properties of human tolerogenic dendritic cells could be mediated by retinoic acid which, in addition to its known role in favouring T cell differentiation to FoxP3+ regulatory T cells, acts to convert B cells into immunosuppressive cells." @default.
• W1506579269 created "2016-06-24" @default.
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• W1506579269 date "2013-10-06" @default.
• W1506579269 modified "2023-10-14" @default.
• W1506579269 title "Retinoic acid-producing,<i>ex-vivo</i>-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes" @default.
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• W1506579269 doi "https://doi.org/10.1111/cei.12177" @default.
• W1506579269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3828834" @default.
• W1506579269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23865694" @default.
• W1506579269 hasPublicationYear "2013" @default.
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